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Edex Coupon - Edex 2 cartridges of 20mcg package

Edex

alprostadil
Used for Erectile Dysfunction
Used for Erectile Dysfunction

Alprostadil injection is a prescription medication that treats erectile dysfunction (ED). It's given as a shot into the base of the penis before sexual intercourse. A common side effect of this medication is penile pain. Alprostadil injection is available under a few different brand names, including Caverject and Edex.

Last reviewed on August 10, 2023
basics-icon

What is Alprostadil injection?

What is Alprostadil injection used for?

  • Treatment of erectile dysfunction (ED)

  • Add-on to other lab tests for the diagnosis of erectile dysfunction - Caverject and Caverject Impulse only

How Alprostadil injection works

Alprostadil injection is a prostaglandin analog. It relaxes the muscles around your penis and opens the blood vessels to allow more blood to flow into the penis, resulting in the ability to have an erection.

Are you looking for information on Muse (alprostadil) instead?

Drug Facts

Drug ClassProstaglandin analog
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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$285.02(save 65.38%)
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$98.67
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What are the side effects of Alprostadil injection?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Penile pain (up to 37%)

Other Side Effects

  • Bleeding at injection site
  • Penile curvature
  • Scar tissue in the penis
  • Erections lasting longer than 4 hours
  • Bruising at injection site
  • Blood pooling (hematoma) at or near the injection site

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Prolonged erection (erection lasting longer than 4 hours)
  • Heart problems: chest pain, dizziness, nausea

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare

Curving of penis with pain during erection

erection continuing for 4 to 6 hours

erection continuing longer than 6 hours with severe and continuing pain of the penis

swelling in or pain of the testes

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Bleeding and pain at the injection site (short-term)

painful erection

Rare

Bruising or clotted blood in the penis at the injection site, usually caused by an incorrect injection

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Alprostadil injection

thumbs-up

Pros

Starts to work quickly within 5 to 20 minutes

Can last for up to 1 hour

Caverject Impulse and Edex are available in dual chamber syringes or cartridges that make them easier to prepare

thumbs-down

Cons

Needs to be injected directly into the penis

Might be difficult for some people to administer correctly

Can cause pain in the penis

pharmacist-tips

Pharmacist tips for Alprostadil injection

pharmacist
  • Alprostadil injection shouldn't be used more than 3 times per week and shouldn't be given more often than 1 time every 24 hours.

    • You should receive training from your provider on how to give yourself alprostadil injection. Make sure you know how to give yourself alprostadil injection to avoid accidentally hurting yourself or wasting the medication. Contact your provider if you have any questions on how to use this medication.

      • Store Edex, Caverject Impulse, Caverject 20 mcg vials at room temperature before mixing. If you have Caverject 40 mcg vials, store them in the refrigerator before mixing.

        • If you're using Caverject, after the medication is mixed, store it at or below 77ºF (but don't refrigerate or freeze the medication) and use the dose within 24 hours. If you're using Caverject Impulse, after the medication is mixed, store it between 36ºF to 77ºF (but don't freeze the medication) and use the dose within 24 hours. If you're using Edex, use the dose right away after mixing it, don't store it for future use.

          • Wipe the site of injection with an alcohol wipe before injection in order to clean the area. After injecting, hold a sterile gauze or alcohol wipe to the injection site for 5 minutes to prevent or stop bleeding.

            • Only inject alprostadil injection into the side or base, on the lower one-third of your penis. Make sure to alternate injection sites and the sides of your penis that's injected to avoid skin irritation and pain. Don't inject into visible veins. Doing so can cause the medication to get into your blood stream, which can cause serious heart side effects.

              • After giving yourself the medication, throw the needle and syringe away in a sharps container or something made of heavy-duty plastic, such as an empty milk carton or laundry detergent bottle, to lower the risk of needle-stick injuries. Don't throw away needles or syringes in your trash can. When your sharps container is almost full, close it tightly with the cap. For more information on how to throw away your sharps container safely and guidance for your specific state, visit the FDA's website.

                • Each alprostadil injection vial (Caverject), syringe (Caverject Impulse), and cartridge (Edex) should only be used once. Throw them away after you administer the injection. Don't save any leftover medication to avoid infections.

                  • Always check the medication solution to make sure it's clear and colorless before using it. If it's cloudy, discolored, or has particles (solid chunks), don't use it.

                    • If the needle is bent, throw it away into a sharps container and attach a new, unused needle. Don't try to straighten it because you might poke yourself. Don't re-use or share needles to avoid spreading infections.

                      • Get medical help right away if you have an erection that lasts longer than 4 hours so you can receive treatment to prevent permanent damage to your penis.

                        • You should see your provider every 3 months for check-ups to make sure it's safe for you to continue taking alprostadil injection and to examine your penis for side effects, such as scarring, skin irritation, and changes in skin color.

                          faqs

                          Frequently asked questions about Alprostadil injection

                          Does alprostadil injection work?
                          Yes. In clinical studies looking at how well the medication works, 94% of males using alprostadil injection reported they were able to have sex after the injection. Over 85% of the males and their partners reported the sexual experience to be satisfactory.
                          How long does it take alprostadil injection to start working?
                          Alprostadil injection typically starts to work within 5 to 20 minutes. It should last no longer than 1 hour. Contact your provider if your erection lasts longer than 1 hour. This might mean your alprostadil injection dose is too high and having an erection for a long time (priapism) can cause damage your penis.
                          How long does alprostadil injection last?
                          At the appropriate dose, the effects of alprostadil injection should last up to an hour. If the erection lasts more than an hour, let your provider know right away. This likely means that your dose is too high and needs to be adjusted. Your provider will check in with you every 3 months to see if the dose of alprostadil injection is safe and working well for you, and make changes as needed.
                          How often can you use alprostadil injection?
                          You can use alprostadil injection up to 3 times per week, with each injection separated by at least 24 hours.
                          Can you mix sildenafil (Viagra) and alprostadil injection?
                          Ask your provider if it's safe and appropriate for you to take both sildenafil (Viagra) and alprostadil injection at the same time. There have been studies that looked at combining a phosphodiesterase-5 (PDE-5) inhibitor, like sildenafil (Viagra), with alprostadil injection. Research suggest that this combination can be an option for people who didn't get good results from either medication. Talk to your provider if you have more questions about this combination.
                          What's the difference between Edex and Caverject?
                          Both Edex and Caverject are brand names of alprostadil injection. The main difference is how they're packaged, which can affect ease of injection. Caverject comes in a vial containing a powder. You'll need to mix it before you use it, using syringe with needle, and sterile water. Both Caverject Impulse and Edex come in dual chambers syringe, which make mixing and injecting easier.
                          What's the difference between Caverject and Muse?
                          Both Caverject and Muse contain the same active ingredient, alprostadil. A major difference between them is Caverject is given as an injection into the base of the penis, whereas Muse is a suppository that's inserted into the urethra (the tube that drains the bladder) of the penis. Some people might prefer Muse because it's not an injection, studies comparing both medications found that about 70% of males using Muse reported poor erection quality, compared to 12% of males using Caverject. Another important difference is that Muse shouldn't be used for sexual intercourse with a pregnant female unless a condom barrier is used to protect the unborn baby from exposure to the medication.
                          How do you inject alprostadil injection?
                          The technique needed to properly inject alprostadil injection differs based on the specific brand-name medication you're using. Read the instructions (Caverject, Caverject Impulse, or Edex) for use for the medication you're prescribed and contact your provider or pharmacist if you have any questions on how to use this medication safely and correctly.
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                          What are the risks and warnings for Alprostadil injection?

                          Alprostadil injection can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                          risk-warning

                          Prolonged erection (priapism)

                          • Risk factors: History of conditions that raise the risk of prolonged erections | Higher doses of alprostadil injection

                            Get medical help right away if you get an erection that lasts longer than 4 hours after using alprostadil injection. If this isn't treated right away, it can lead to permanent damage to your penis. Alprostadil injection shouldn't be used by people who have a history of medical conditions that raise the risk of prolonged erections, such as sickle cell anemia, multiple myeloma, and leukemia. To minimize your risk of a prolonged erection, your provider will only prescribe the lowest dose of alprostadil injection needed produce an erection that lasts for at most 1 hour. Your provider will check in with you every 3 months to see if your dose of alprostadil injection needs to be adjusted. Contact your provider if you want to try and lower your dose, but don't change it on your own.

                            risk-warning

                            Penile scarring

                            • Risk factors: Taking alprostadil injection for a long time

                              Although rare, alprostadil injection can cause scarring on your penis, which can lead to penile curvature. Your provider will do physical examinations regularly to see if there's scarring. If so, they'll ask you to stop taking alprostadil injection.

                              risk-warning

                              Low blood pressure

                              • Risk factors: Taking other medications that lower your blood pressure

                                Taking alprostadil injection can cause low blood pressure. This can lead to symptoms such as dizziness, lightheadedness, or fainting. If you feel any of these symptoms, make sure to sit down right away so you don't fall. To lower your risk of low blood pressure, you should take the lowest dose possible of alprostadil injection.

                                risk-warning

                                Bleeding at the injection site

                                Using alprostadil injection can lead to minor bleeding at the injection site. If you're taking blood thinners or have a condition where you bleed more easily, your risk of bleeding after using alprostadil injection might be higher. After injection, make sure to hold a sterile gauze or alcohol swab over the injection site for 5 minutes to stop the bleeding. Talk to your provider about the risks and benefits of using alprostadil injection if you're taking blood thinners.

                                risk-warning

                                Heart problems from sex

                                • Risk factors: History of heart problems

                                  Having sexual intercourse can put a lot of stress on your heart, which can be especially problematic if you have a history of heart problems. Alprostadil injection shouldn't be used if your provider advised you not to participate in sexual activity because of your heart problems. Contact your provider right away if you get symptoms of a heart problem, such as chest pain, dizziness, or nausea.

                                  risk-warning

                                  Needle breakage

                                  • Risk factors: Injecting alprostadil injection incorrectly

                                    Alprostadil injection must be injected with a very thin needle. It's possible that these needles can break in your penis while you're giving yourself the injection. In some cases, people have had to go the hospital and have surgery to get the needle removed. Make sure you understand how to give yourself alprostadil injection and ask your provider or pharmacist if you have any questions.

                                    risk-warning

                                    Not for children

                                    Caverject and Caverject Impulse contains an ingredient, called benzyl alcohol, that can cause serious and life-threatening side effects such as "gasping syndrome" in children. Only Prostin VR, a specific brand name of intravenous alprostadil injection, is used in hospital for newborns with certain heart conditions. But Caverject, Caverject Impulse, and edex should never be used in children.

                                    risk-warning

                                    Sexually transmitted infections

                                    Alprostadil injection doesn't protect you from sexually transmitted infections (STIs), including human immunodeficiency virus (HIV). To protect yourself and others from STIs, you should use condoms, get tested for STIs regularly, and limit your number of sexual partners. Female partners who are of childbearing age should consider using birth control.

                                    dosage

                                    Alprostadil injection dosage forms

                                    The average cost for 1 package of 2 cartridges of 20mcg of Alprostadil injection is $212.93 with a free GoodRx coupon. This is 25.29% off the average retail price of $285.02.
                                    package
                                    Package
                                    DosageQuantityPrice as low asPrice per unit
                                    2 cartridges of 10mcg1 package$98.67$98.67
                                    6 cartridges of 10mcg1 package$633.00$633.00
                                    2 cartridges of 20mcg1 package$212.93$212.93
                                    6 cartridges of 20mcg1 package$246.59$246.59
                                    2 cartridges of 40mcg1 package$321.16$321.16
                                    6 cartridges of 40mcg1 package$948.66$948.66

                                    Typical dosing for Alprostadil injection

                                    Treatment of ED:
                                    Your provider will give you the first few alprostadil injections at their office to determine the right dose for you. The typical starting dose ranges from 1.25 mcg to 2.5 mcg injected into the base of the penis. If needed, your provider will adjust the dose based on your response.

                                    • Inject the dose determined at your provider's office into the base of the penis. This can range from 1 mcg to 40 mcg for edex, and up to 60 mcg for Caverject and Caverject Impulse. Don't use alprostadil injection more than 3 times a week. Make sure there's at least 24 hours in between each dose.

                                    Diagnosis of ED (Caverject and Caverject Impulse only):

                                    • Together with lab testing, your provider will inject 1 dose of Caverject or Caverject Impulse into the base of your penis and monitor for an erection.

                                    interactions

                                    Interactions between Alprostadil injection and other drugs

                                    Alprostadil injection may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Alprostadil injection. Please note that only the generic name of each medication is listed below.

                                    Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                                    • Heparin
                                    drug-cost

                                    How much does Alprostadil injection cost?

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                                    contraindications-icon

                                    Alprostadil injection contraindications

                                    Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Alprostadil injection will not be safe for you to take.
                                    • Conditions that can cause long-lasting erections (e.g., sickle cell anemia, leukemia, or multiple myeloma)

                                    • Abnormally-formed penis or Peyronie's disease

                                    • Men with implants in the penis

                                    alternatives

                                    What are alternatives to Alprostadil injection?

                                    There are a number of medications that your doctor can prescribe in place of Alprostadil injection. Compare a few possible alternatives below.
                                    Alprostadil injection
                                    Used for:
                                    • Treatment of erectile dysfunction (ED)

                                    • Add-on to other lab tests for the diagnosis of erectile dysfunction - Caverject and Caverject Impulse only

                                    $98.67 Lowest GoodRx priceView Prices
                                    Used for:
                                    • Erectile dysfunction (ED)

                                    $12.56 Lowest GoodRx priceView Prices
                                    $472.40 Lowest GoodRx priceView Prices
                                    images

                                    Alprostadil injection images

                                    white - Edex Cartridge 20mcg Powder for Injection
                                    This medicine is White Package.white - Edex Cartridge 20mcg Powder for Injection

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                                    References

                                    Best studies we found

                                    Endo Pharmaceuticals Inc. (2018). edex® (alprostadil for injection).

                                    Endo Pharmaceuticals Inc. (2022). Edex- alprostadil injection, powder, lyophilized, for solution [package insert]. DailyMed.

                                    Fitkin, J., et al. (1999). Peyronie's disease: Current management. American Family Physician.

                                    View All References (9)

                                    Linet, O. I., et al. (1996). Efficacy and safety of intracavernosal alprostadil in men with erectile dysfunction. The New England Journal of Medicine.

                                    MedGen. (n.d.). Gasping syndrome. National Library of Medicine.

                                    Nehra, A. (2007). Oral and non-oral combination therapy for erectile dysfunction. Reviews in Urology.

                                    Pfizer Inc. (2023). Caverject® Impulse instructions for use.

                                    Pharmacia & Upjohn Company LLC. (2022). Caverject Impulse- alprostadil injection, powder, lyophilized, for solution [package insert]. DailyMed.

                                    Pharmacia & Upjohn Company LLC. (2023). Caverject- alprostadil injection, powder, lyophilized, for solution [package insert]. DailyMed.

                                    Pharmacia and Upjohn Company LLC. (2020). Prostin VR Pediatric- alprostadil injection, solution [package insert]. DailyMed.

                                    ScienceDirect. (n.d.). Prostaglandin E1.

                                    U.S. Food and Drug Administration. (2021). Safely using sharps (needles and syringes) at home, at work and on travel.

                                    GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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