Diflorasone (Apexicon E) is one of the strongest topical steroid medications used to relieve inflammation and itching caused by various skin conditions. It's applied to the skin, typically one to three times a day. Some of the more common side effects of diflorasone (Apexicon E) include mild burning or itching. But it generally doesn't cause many serious side effects if used short-term as directed by your provider. Diflorasone is available as a cream or ointment.
Inflammatory skin conditions
Diflorasone (Apexicon E) is a topical corticosteroid. It helps treat flare-ups of skin conditions by calming down the immune system and lessening inflammation.
Source:Â DailyMed
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Incidence not known
Blindness
blistering, burning, crusting, dryness, or flaking of the skin
blurred vision
decreased vision
headache
irritation
itching, scaling, severe redness, soreness, or swelling of the skin
redness and scaling around the mouth
tearing
thinning of the skin with easy bruising, especially when used on the face or where the skin folds together (eg, between the fingers)
vomiting
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
burning and itching of the skin with pinhead-sized red blisters
burning, itching, and pain in hairy areas, or pus at the root of the hair
increased hair growth on the forehead, back, arms, and legs
lightening of normal skin color or of treated areas of dark skin color
reddish purple lines on the arms, face, legs, trunk, or groin
softening of the skin
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
One of the strongest topical steroids available
Low risk of serious side effects if used for short periods of time
Available as a lower-cost generic
Available as a cream and an ointment
Can cause skin irritations, such as dry skin and acne
Not well-studied in children, but likely higher risk of side effects in children
Unknown if safe to use in pregnant or breastfeeding females
Can't be used to treat skin infections
Before applying diflorasone (Apexicon E), make sure the affected areas of skin are clean and dry. When you apply the medication, be sure to rub it in gently and completely.
After you've applied diflorasone (Apexicon E), avoid touching other areas of skin, other people, or pets until you've wash your hands well. This will help prevent the medication from accidentally being transferred to others or other parts of your body that don't need the medication.
Avoid getting diflorasone (Apexicon E) in your eyes. Don't rub your eyes after applying this medications, until you've washed your hands. Doing so can raise your risk of vision problems.
Only apply the smallest amount of diflorasone (Apexicon E) needed to cover the affected areas of your skin. Also, only use diflorasone (Apexicon E) for the amount of time your provider instructed you to use it. Doing so will lower your risk of side effects, such as skin irritations.
You might notice some mild burning or itching after applying diflorasone (Apexicon E). But if your symptoms are severe or if a rash appears afterward, contact your healthcare provider. You might need more medical attention.
Don't place bandages or dressings over the areas where diflorasone (Apexicon E) is applied unless your provider has instructed you to do so. Doing so can cause your skin to absorb more medication, which can raise your risk of side effects, such as skin irritations.
Check with your provider first before using other corticosteroid products with diflorasone (Apexicon E). Using multiple corticosteroids raises your risk of serious side effects, such as hormone changes and skin sensitivity.
Diflorasone (Apexicon E) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Risk factors: Applying diflorasone (Apexicon E) to large areas of the body | Using diflorasone (Apexicon E) for a long time | Covering the medicated area with bandages | Younger age
If you absorb too much diflorasone (Apexicon E) through the skin, you can experience symptoms of too much stress hormones, such as bruising easily or high blood sugar levels.
In addition, absorbing too much diflorasone (Apexicon E) can also cause your body to make less of its own stress hormones. This becomes a problem when you stop using diflorasone (Apexicon E) and your body can't ramp up making its own stress hormones quickly enough. This can put you at risk for a problem called adrenal insufficiency, where you have too little stress hormone.
To lower your risk of these problems, don't use more diflorasone (Apexicon E) than what's prescribed by your provider. Also, don't put any bandages over skin areas where you just applied the medication. Don't stop using diflorasone (Apexicon E) unless your provider tells you to do so. Sometimes, your provider might need to lower how often you apply this medication slowly over time, before you can safely stop it. Your body will typically recover from these problems after you stop using diflorasone (Apexicon E).
Skin irritation and changes, including burning, itching, dryness, inflammation of hair follicles, excessive hair growth, and changes in skin color, have occurred from using diflorasone (Apexicon E). Let your provider know if you experience any of these side effects.
Diflorasone (Apexicon E) can lower your body's ability to fight infections, including infections on your skin. It's especially important to treat skin infections with an appropriate antifungal or antibacterial if you're using diflorasone (Apexicon E). The longer you're using this medication, the higher your risk of this problem is. If you notice redness, pain, swelling, or pus where you're applying diflorasone (Apexicon E), stop using it and talk to your healthcare provider right away.
Topical steroids can raise your risk for eye problems such as cataracts and glaucoma. This is more commonly seen in people who applied topical steroid drops into their eyes for various eye conditions. However, are reports of this happening in people who used diflorasone (Apexicon E) for skin conditions. If you notice any changes in your vision, contact your provider.
The typical dose is to apply to the affected area(s) 1 to 3 times a day as instructed by your healthcare provider.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
Inflammatory and itchy skin conditions
Inflammatory and itchy skin conditions
By providing your email, you consent to receive marketing communications from GoodRx, which may include content and/or data related to men’s health, women's health, reproductive care, or sexual health. You agree to the GoodRx Terms of Use and acknowledge the Privacy Policy. You can unsubscribe at any time.
American Academy of Dermatology Association. (n.d.). Psoriasis clinical guideline.
ANI Pharmaceuticals. (2022). Apexicon E - diflorasone diacetate cream [package insert]. DailyMed.
Ference, J. D., et al. (2009). Choosing topical corticosteroids. American Family Physician.Â
National Institute of Diabetes and Digestive and Kidney Diseases. (2018). Cushing's syndrome.
National Institute of Diabetes and Digestive and Kidney Diseases. (2018). Symptoms and causes of adrenal insufficiency and Addison's disease.
Sihota, R., et al. (2006). Prospective, long-term evaluation of steroid-induced glaucoma. Eye.
Taro Pharmaceuticals U.S.A. (2020). Diflorasone diacetate ointment [package insert]. DailyMed.
Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.