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Crinone

Crinone Side Effects

Kristianne Hannemann, PharmDCydnee Ng, PharmD
Reviewed by Kristianne Hannemann, PharmD, Cydnee Ng, PharmD
Last reviewed on May 31, 2024

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Breast growth (40%)
  • Sleepiness (27%)
  • Constipation (27%)
  • Nausea (22%)
  • Headache (17%)
  • Pain around the vaginal opening (17%)
  • Nervousness (16%)
  • Needing to urinate in the middle of the night (13%)
  • Stomach pain (12%)
  • Depression (11%)
  • Lowered sex drive (10%)

Less Common Side Effects

  • Diarrhea
  • Vomiting
  • Joint pain
  • Pain during sex
  • Vaginal discharge

Note: Side effects were reported by people who used Crinone 8% gel once daily for fertility treatment.

Crinone serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Blood clot and its complications: swelling or tenderness in the leg; chest pain; pain that spreads to the shoulder, arm, or jaw; sudden trouble talking or walking; sudden numbness on one side of the body; severe headache; trouble breathing

Source: DailyMed

The following Crinone side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare

Signs of toxic shock syndrome—for cervical caps or diaphragms

Chills

confusion

dizziness

fever

lightheadedness

muscle aches

sunburn-like skin rash that is followed by peeling of the skin

unusual redness of the inside of the nose, mouth, throat, vagina, or eyelids

Check with your doctor as soon as possible if any of the following side effects occur:

Rare

For females and males

Skin rash, redness, irritation, or itching that does not go away within a short period of time

For females only

Cloudy or bloody urine

increased frequency of urination

pain in the bladder or lower abdomen

thick, white, or curd-like vaginal discharge—with use of cervical caps or diaphragms only

vaginal irritation, redness, rash, dryness, or whitish discharge

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Vaginal discharge (temporary)—with use of creams, foams, and suppositories

vaginal dryness or odor

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Kristianne Hannemann, PharmD, is a licensed pharmacist in California. She has been a retail pharmacy manager and staff pharmacist for over 7 years and has contributed drug information content to different health companies.
Cydnee Ng, PharmD
Reviewed by:
Cydnee Ng, PharmD
Cydnee Ng, PharmD, is a drug information pharmacist at GoodRx, where she lends her expertise to providing reader-friendly, accessible content about medications. She holds her pharmacist license in California.

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