Can These 10 Supplements Help Treat Allergies? We Give You the Answers
Key takeaways:
Many supplements have been marketed for treating seasonal allergies, but not all of them are helpful or worth trying.
There’s some evidence that supplements like quercetin, zinc, and stinging nettle may improve symptoms of seasonal allergies like runny nose and congestion. They may work by blocking the release of histamines or reducing inflammation.
Supplements like butterbur, honey, and bromelain don’t have solid evidence to suggest they’re helpful for allergy symptoms.
Table of contents
If you have allergies, the changing of the seasons may be a time of year that you dread. Outdoor allergens — like plant pollen and mold — can bring on symptoms like runny nose, itchy eyes, and sneezing.
You might feel like your only choices are to suffer through it or rely on medications. But some natural supplements and remedies may help treat allergy symptoms. Here we’ll review a list of 10 common supplements for allergies. We’ll discuss the research behind them, their effectiveness, and give you clear guidance on which ones are actually worth trying.
1. Quercetin
What is it?
Stay healthy with CVS
Shop the brands you trust at CVS. Whether it’s wellness or beauty, get what you need at great prices.
Quercetin is a type of plant pigment called a flavonoid. It works as a natural antihistamine. This means it helps block the release of histamines — molecules your immune system releases. Histamines are what cause allergy symptoms like a runny nose and congestion.
The evidence
In addition to blocking histamines, there’s evidence from lab and animal studies that quercetin has other anti-allergy and antiviral properties. It may also reduce inflammation caused by allergy symptoms.
Research in humans is limited, but one study found that people who ate more quercetin-rich foods had lower rates of respiratory allergies, like asthma. Quercetin is found in a variety of foods, including:
Apples
Onions
Berries
Any health risks?
DIY allergy care: If your allergies are causing nose and throat symptoms, these home remedies can help clear your congestion.
Allergy medication options: If supplements aren’t cutting it, there are many different types of allergy medications you can try.
Lifestyle changes for relief: Three people explain the changes they made to get rid of their allergy symptoms.
Quercetin has minimal side effects when taken in doses of 1,000 mg or less per day. When side effects do happen, they’re usually mild, like an upset stomach or headaches.
Some animal studies suggest that high doses of quercetin could lead to serious risks, like kidney damage or tumor growth. But these effects haven’t been seen in humans.
Is it worth a try?
It might be. Many lab and animal studies show that quercetin has strong anti-allergy effects. While research in humans is limited, it’s promising. But people with chronic health conditions should always check with their healthcare professional before starting quercetin. This is especially important if you take prescription medications, as it can interact with certain medications.
2. Zinc
What is it?
Zinc is a natural mineral found in many foods. It helps your body grow and develop. Zinc may be best known for its role in strengthening your immune system. But it also plays a role in wound healing, taste sensation, and allergic responses.
The evidence
Zinc may help reduce inflammation caused by allergies. People with a zinc deficiency are up to five times more likely to have allergies than those without a deficiency.
One study of almost 2,000 people found that lower blood levels of zinc were linked to increased levels of allergy-specific antibodies, known as immunoglobulin E (IgE). Higher IgE levels are linked to higher rates of seasonal allergies and other types of allergies. This may explain why another study found that taking zinc supplements can help reduce seasonal allergy symptoms.
Any health risks?
High doses of oral zinc supplements can cause symptoms like diarrhea, stomach cramping, and vomiting within a few hours of taking them. Nasal sprays containing zinc might cause a temporary loss of smell. But any side effect is likely to go away quickly. With zinc supplements, don’t take more than the recommended upper limit of 40 mg per day.
Is it worth a try?
Probably. Like quercetin, zinc is a promising supplement for allergies. While larger studies in humans are needed, current evidence suggests it may help improve allergy symptoms. It also has a low risk of side effects.
You can also boost your zinc intake by eating foods rich in zinc, such as:
Oysters
Turkey breast
Pumpkin seeds
3. Turmeric
What is it?
Turmeric comes from a type of root vegetable that’s used as a spice for seasoning food. Its active compound, curcumin, is responsible for most of its known health benefits and gives turmeric its yellow color.
The evidence
There’s good evidence that turmeric can help with inflammatory conditions like arthritis. The evidence that it helps with seasonal allergies is more limited. Most studies are from animals or in labs.
One human study looked at people with hay fever (allergic rhinitis). It found that taking curcumin supplements by mouth for 2 months led to less sneezing and runny nose.
Any health risks?
Turmeric is generally safe. But some people could have side effects of diarrhea and stomach pain at doses higher than 450 mg per day.
If you’re pregnant, it’s not recommended to take turmeric supplements because some animal studies showed risks during pregnancy. But eating foods that contain turmeric spice, such as curry, is believed to be safe even when pregnant or nursing.
Is it worth a try?
Possibly. There’s some evidence that turmeric supplements can help with seasonal allergies taken daily for several months. It may also have other benefits as an anti-inflammatory treatment for conditions like arthritis.
4. Probiotics
What are they?
Probiotics are live microorganisms — like bacteria — that are good for your gut. They play a role in supporting a balanced microbiome. This makes them also potentially helpful in supporting a variety of other aspects of health, including your immune system and heart health.
The evidence
Probiotics have been shown to help support immune system function. A review of 28 studies concluded that probiotics help improve allergy symptoms. But the results were inconsistent between studies.
Another study also raised concerns about variability in the research. Whether probiotics can treat allergies depends on factors like the strain of bacteria, dosage, and how they’re taken. The study also reported that the most beneficial probiotic strain for allergies isn’t yet known.
Any health risks?
Probiotics aren’t likely to cause side effects in generally healthy people. Possible mild side effects may include digestive issues, like bloating and gas. But they may pose a risk for those with weakened immune systems, potentially leading to infections. The risk of side effects may be higher in premature infants, hospitalized people, and those with serious medical conditions.
Is it worth a try?
If you have a healthy immune system, probiotics are a safe supplement that may offer multiple health benefits. These include a potential to provide allergy relief. But the best strains and dosages are still unclear, and some brands can be expensive.
You can also increase your probiotic intake by eating fermented foods and beverages like kefir. These are a good source of natural probiotics.
5. Butterbur
What is it?
Butterbur is a type of plant that grows in parts of North America, Europe, and Asia. It got its name because people used to wrap it around butter in warm weather.
For centuries, it has been used to treat many health issues, like:
Cough
Upset stomach
Allergies
The evidence
Some studies suggest that butterbur extracts may help with allergy symptoms, but the evidence isn’t strong. Much of the research is outdated, and newer, more thorough research is needed.
Any health risks?
Some butterbur supplements may contain chemicals known as pyrrolizidine alkaloids. These can cause damage to parts of your body like your liver and lungs — and may even cause cancer.
Due to concerns about possible liver damage, the Academy of Neurology stopped recommending butterbur supplements for migraines in 2015.
Other possible side effects may include things like itchy eyes, headache, and fatigue.
Is it worth a try?
No. There isn’t enough recent evidence to suggest butterbur helps with allergy symptoms. More importantly, the potential health risks are serious. It’s best to stick to safer supplements with stronger scientific evidence.
6. Vitamin C
What is it?
Vitamin C, also known as ascorbic acid, is a potent antioxidant that supports your immune system. Since your body can’t make vitamin C, you need to get it from food or supplements.
The evidence
One study had participants take 2,000 mg of vitamin C for 8 weeks and do exercise. The study reported that this combination of vitamin C and exercise significantly improved allergy symptoms like runny nose, sneezing, and congestion.
Most other recent studies on vitamin C and allergies have been small, done in animals, or used other forms of vitamin C other than oral supplements.
Any health risks?
There’s some evidence that high doses of vitamin C could cause kidney stones in men, though no link has been found in women. Otherwise, vitamin C is considered safe, even at high doses.
The most common side effects include mild digestive issues like nausea, diarrhea, and stomach cramps. To avoid these, it’s best to stay at or below the recommended upper limit of 2,000 mg per day.
Is it worth a try?
Yes, vitamin C is a low-risk, affordable supplement, so it’s worth trying if you’re curious. While research on its effect on allergies is still emerging, some evidence suggests it may help lower allergy symptoms.
In addition to supplements, some foods rich in vitamin C include:
Citrus fruits
Strawberries
Broccoli
7. Honey
What is it?
Most people enjoy the taste of honey and how it adds a touch of sweetness to foods. But many people don’t know that certain types of honey may also have health benefits. For example, some claim that honey can help treat seasonal allergies.
The evidence
A study from 2013 looked into this claim. Researchers gave a group of people with seasonal allergies either raw honey or a placebo. Both groups also took an antihistamine. After 8 weeks, the group who ate real honey had improved symptoms compared to the placebo group. But this was a small study, and participants consumed a lot of honey, making it hard to draw firm conclusions.
Any health risks?
In rare cases, consuming raw honey causes an immediate allergic reaction in people with severe seasonal allergies. This is due to the pollen in honey.
Honey is also high in sugar, with 17 g per tablespoon. Eating a lot of it — especially alongside other sugary foods — may lead to exceeding the recommended amounts of sugar per day.
Lastly, honey can cause botulism if it’s given to infants younger than 12 months old, so it should never be used to treat allergies in babies.
Is it worth a try?
No. There isn’t enough research to recommend using honey to treat seasonal allergies. But honey can be worth a try to help soothe a cough.
8. Stinging nettle
What is it?
Stinging nettle is a plant that has been used around the world as medicine for a long time.
The evidence
Lab studies suggest that stinging nettle may have anti-allergy activity. It may work by blocking histamine receptors and lowering mast cells, which can cause inflammation.
A small study found that taking stinging nettle helped improve the management of seasonal allergies, but it wasn’t significantly better than taking a placebo.
Any health risks?
Research has found that having stinging nettle extracts as a supplement is well tolerated with minimal or no side effects. If side effects do occur, they may include things like headache, nausea, or change in bowel habits.
Is it worth a try?
Not yet. While lab studies show promise, there isn’t enough strong human research to confirm that stinging nettle works well to treat seasonal allergy symptoms.
9. Spirulina
What is it?
Spirulina, or Arthrospira platensis, is a type of algae. It has become one of the most well-known algae supplements due to its bioactive compounds with reported health benefits.
The evidence
Spirulina has both antioxidant and anti-inflammatory effects. In a study of 65 people with seasonal allergies, spirulina was compared to the anti-allergy medication cetirizine. Half of the participants took 2 g of spirulina daily, while the other half took 10 mg of cetirizine for 2 months.
The study found that spirulina worked better than cetirizine to lessen symptoms like runny nose, nasal congestion, and trouble smelling. The main downside was that spirulina had to be taken four times a day.
Other studies have also reported that spirulina can significantly improve allergy symptoms compared to a placebo.
Any health risks?
There are few known side effects of taking spirulina for generally healthy people. Some people have reported possible stomach problems and insomnia. It can also negatively interact with certain types of medications.
Spirulina also has a risk of being contaminated with toxic microorganisms. This is because it’s often produced in open ponds, which may contain contaminated water.
Is it worth a try?
It could be, with a few precautions. Anyone with chronic health conditions or who takes daily medications should check with a healthcare professional. The potential drug interactions are a risk. Also, given the risk for contamination, it’s important to buy spirulina only from reputable brands to make sure you’re getting the purest and safest form possible.
10. Bromelain
What is it?
Bromelain is a natural enzyme found in pineapple. It’s promoted as a dietary supplement for many different health issues, such as digestive disorders, pain, and wounds.
The evidence
Most research on bromelain is more than 10 years old and has been done in rodents. These studies suggest that bromelain may help reduce inflammation in the airways, which can lead to breathing problems — a symptom of some people with allergies. However, it’s not clear if this research applies to humans. There isn’t enough high-quality research to recommend bromelain for allergy treatment.
Any health risks?
There are few reported side effects of bromelain in studies. Mild side effects that may occur include upset stomach and diarrhea.
Is it worth a try?
No. While bromelain may be helpful for other health conditions, it shouldn’t be used to treat allergies.
Frequently asked questions
Quercetin and zinc show promise as natural antihistamines. Stinging nettle may also block histamine receptors.
Some research has found a link between low levels of vitamin D and a higher sensitivity to some allergens in children. In other words, vitamin D may help protect against food allergies, though it’s too early to say for sure. This doesn’t mean that vitamin D can reverse or even help manage allergy symptoms. More research is needed to better understand the relationship between vitamin D and allergies.
No, allergies aren’t a sign of a weak immune system. In fact, an allergic reaction occurs when your immune system launches too strong of a response to something in your environment. In other words, your immune system mistakes something harmless, like a food, for a threat and overreacts. This overreaction can lead to bothersome and even life-threatening symptoms.
The bottom line
There are many different types of supplements for allergies. While many don’t have enough research to support their effectiveness in treating allergies, some do show promise.
Supplements like quercetin, zinc, and turmeric may help reduce seasonal allergy symptoms. These can be used alongside or in place of conventional medicines. Just remember to always talk with your healthcare team before starting or stopping any new supplement or medication.
Why trust our experts?
References
Alafiatayo, A. A., et al. (2019). Phytochemical evaluation, embryotoxicity, and teratogenic effects of Curcuma longa extract on zebrafish (Danio rerio). Evidence-Based Complementary and Alternative Medicine.
American Academy of Asthma, Allergy, and Immunology. (2017). Seasonal allergies.
American Academy of Asthma, Allergy, and Immunology. (2024). Vitamin D and food allergy.
American Heart Association. (2024). How much sugar is too much?
Andreas, S., et al. (2018). Safety aspects of the use of Quercetin as a dietary supplement. Molecular Nutrition & Food Research.
Asha’ari, Z. A., et al. (2013). Ingestion of honey improves the symptoms of allergic rhinitis: Evidence from a randomized placebo-controlled trial in the East Coast of Peninsular Malaysia. Annals of Saudi Medicine.
Bakhshaee, M., et al. (2017). Efficacy of supportive therapy of allergic rhinitis by stinging nettle (Urtica dioica) root extract: A randomized, double-blind, placebo- controlled, clinical trial. Iranian Journal of Pharmaceutical Research.
Bhusal, K. K., et al. (2022). Nutritional and pharmacological importance of stinging nettle (Urtica dioica L.): A review. Heliyon.
Calella, P., et al. (2022). Antioxidant, anti-inflammatory and immunomodulatory effects of spirulina in exercise and sport: A systematic review. Frontiers in Nutrition.
Carr, A. C., et al. (2017). Vitamin C and immune function. Nutrients.
David, A. W. A., et al. (20 ). Overviews of biological importance of Quercetin: A bioactive flavonoid. Pharmacognosy Review.
Dewi, A. M., et al. (2019). The effect of zinc supplementation on the improvement of clinical symptoms and the quality of life of persistent moderate severe allergic rhinitis patients. Frontiers in Pharmacology.
Ferraro, P. M., et al. (2015). Total, dietary, and supplemental vitamin C intake and risk of incident kidney stones. American Journal of Kidney Diseases.
Ghalibaf, M. H. E., et al. (2023). The effects of vitamin C on respiratory, allergic and immunological diseases: An experimental and clinical-based review. Inflammopharmacology.
Hewlings, S. J., et al. (2017). Curcumin: A review of its’ effects on human health. Foods.
Jafarinia, M., et al. (2020). Quercetin with the potential effect on allergic diseases. Allergy, Asthma, and Clinical Immunology.
Karkos, P. D., et al. (2010). Spirulina in clinical practice: Evidence-based human applications. Evidence-Based Complementary and Alternative Medicine.
Knekt, P., et al. (2002). Flavonoid intake and risk of chronic diseases. The American Journal of Clinical Nutrition.
Kothari, D., et al. (2019). Probiotic supplements might not be universally-effective and safe: A review. Biomedicine and Pharmacotherapy.
Kurup, V. P., et al. (2008). Immunomodulatory effects of curcumin in allergy. Molecular Nutrition & Food Research.
LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. (2023). Stinging nettle. National Institute of Diabetes and Digestive and Kidney Diseases.
Luo, C., et al. (2022). The efficacy and safety of probiotics for allergic rhinitis: A systematic review and meta-analysis. Frontiers in Immunology.
Mazziotta, C., et al. (2022). Probiotics mechanism of action on immune cells and beneficial effects on human health. Cells.
Mlcek, J., et al. (2016). Quercetin and Its anti-allergic immune response. Molecules.
Mohos, V., et al. (2020). Inhibitory effects of Quercetin and its main methyl, sulfate, and glucuronic acid conjugates on cytochrome P450 enzymes, and on OATP, BCRP and MRP2 transporters. Nutrients.
National Center for Integrative and Complementary Health. (2024). Bromelain. National Institute of Health.
National Center for Integrative and Complementary Health. (2024). Butterbur. National Institute of Health.
National Center for Integrative and Complementary Health. (2019). Probiotics: Usefulness and safety. National Institute of Health.
National Center for Integrative and Complementary Health. (2020). Turmeric. National Institute of Health.
Nourallahian, M., et al. (2020). Clinical comparison of the efficacy of spirulina platensis and cetirizine for treatment of allergic rhinitis. Official Journal of the Italian Society of Otorhinolaryngology Head and Neck Surgery.
Office of Dietary Supplements. (2021). Vitamin C. National Institute of Health.
Patel, R. H., et al. (2023). Biochemistry, histamine. StatPearls.
Peng, Y., et al. (2021). Anti-Inflammatory effects of curcumin in the inflammatory diseases: Status, limitations and countermeasures. Drug Design, Development and Therapy.
Rabinovich, D., et al. (2023). Zinc. StatPearls.
Rhoades, J., et al. (2023). Microbiota and cyanotoxin content of retail spirulina supplements and spirulina supplemented foods. Microorganisms.
Roschek Jr., B., et al. (2009). Nettle extract (Urtica dioica) affects key receptors and enzymes associated with allergic rhinitis. Phytotherapy Research.
Salo, P. M., et al. (2011). Allergy-related outcomes in relation to serum IgE: Results from the National Health and Nutrition Examination Survey 2005–2006. The Journal of Allergy and Clinical Immunology.
Schapowal, A. (2002). Randomised controlled trial of butterbur and cetirizine for treating seasonal allergic rhinitis. The BMJ.
Schramm, S., et al. (2019). Pyrrolizidine alkaloids: Biosynthesis, biological activities and occurrence in crop plants. Molecules.
Secor Jr., E. R., et al. (2012). Bromelain limits airway inflammation in an ovalbumin-induced murine model of established asthma. Alternative Therapies in Health and Medicine.
Shabir, I., et al. (2022). Promising bioactive properties of quercetin for potential food applications and health benefits: A review. Frontiers in Nutrition.
Sharifi-Rad, J., et al. (2020). Turmeric and its major compound curcumin on health: Bioactive effects and safety profiles for food, pharmaceutical, biotechnological and medicinal applications. Frontiers in Pharmacology.
Shi, Q., et al. (2023). Zinc supplement reduces allergic responses through modulating the p38 MAPK pathway activation in an allergic rhinitis mouse model. Journal of Trace Elements in Medicine and Biology.
Tongtako, W., et al. (2018). Effects of aerobic exercise and vitamin C supplementation on rhinitis symptoms in allergic rhinitis patients. Asian Pacific Journal of Allergy and Immunology.
Wu, S., et al. (2016). Effect of curcumin on nasal symptoms and airflow in patients with perennial allergic rhinitis. Annals of Allergy, Asthma & Immunology.
Yang, G., et al. (2013). Treatment of allergic rhinitis with probiotics: An alternative approach. North American Journal of Medical Studies.
Zang, J., et al. (2023). Anti-allergic effect of dietary polyphenols curcumin and epigallocatechin gallate via anti-degranulation in IgE/Antigen-stimulated mast cell model: A lipidomics perspective. Metabolites.
