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Compare Xphozah vs. Ibsrela

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Xphozah (tenapanor)
    Ibsrela (tenapanor)
  • Xphozah (tenapanor)
    Ibsrela (tenapanor)

  • Summary of Xphozah vs. Ibsrela

    Summary for NHE3 inhibitor
    Prescription only

    Xphozah (tenapanor) is a prescription medication used to lower phosphate levels in adults with chronic kidney disease (CKD) on dialysis. It's approved to take alone or with phosphate binders. But unlike traditional phosphate binders, Xphozah (tenapanor) works by blocking phosphate from being absorbed in your intestines instead of binding it in your gut. The usual dose is one tablet by mouth twice a day, typically before breakfast and dinner. The most common side effect is diarrhea.

    Summary for Sodium/hydrogen exchanger 3 (NHE3) inhibitor
    Prescription only

    Ibsrela (tenapanor) is used to treat adults with irritable bowel syndrome with constipation (IBS-C). This medication belongs to the drug class called sodium/hydrogen exchanger 3 (NHE3) inhibitors. Ibsrela (tenapanor) is a tablet that's taken by mouth twice per day. There aren't many side effects, but the most common is diarrhea. Other side effects include bloating, gas, and dizziness.

  • Indications of Xphozah vs. Ibsrela

    Indications for
    •Lower phosphate levels in adults with chronic kidney disease (CKD) on dialysis who haven't responded well to or can't take phosphate binders
    Indications for
    •Irritable bowel syndrome with constipation (IBS-C) in adults

  • Pros and Cons of Xphozah vs. Ibsrela

    Pros and Const for NHE3 inhibitor
    Pros
    •Tablet taken by mouth
    •Helpful when phosphate binders alone aren't enough
    •Starts working within the first week
    Cons
    •Must take before breakfast and dinner
    •Diarrhea is a very common side effect
    •Only available through specialty pharmacies
    Pros and Const for Sodium/hydrogen exchanger 3 (NHE3) inhibitor
    Pros
    •Recommended for people with IBS-C who've already tried other therapies
    •Can help lessen episodes of stomach pain and constipation
    •Symptoms can start to improve within a week
    Cons
    •Need to take right before a meal twice daily
    •Can cause diarrhea and dehydration
    •Not safe for children

  • Common Side Effects of Xphozah vs. Ibsrela

    Common Side Effects for
    •Diarrhea (43-53%)
    Common Side Effects for
    •Diarrhea (16%)
    •Stomach bloating (3%)
    •Gas (3%)
    •Dizziness (2%)

  • Warnings of Xphozah vs. Ibsrela

    Common Side Effects for
    •Diarrhea
    Common Side Effects for
    •Serious dehydration in children
    •Diarrhea

  • Prices with our coupons for Xphozah vs. Ibsrela

    Learn more about Xphozah
    Learn more about Ibsrela

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