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Xphozah vs. Ibsrela

Xphozah (tenapanor) is a prescription medication used to lower phosphate levels in adults with chronic kidney disease (CKD) on dialysis. It's approved to take alone or with phosphate binders. But unlike traditional phosphate binders, Xphozah (tenapanor) works by blocking phosphate from being absorbed in your intestines instead of binding it in your gut. The usual dose is one tablet by mouth twice a day, typically before breakfast and dinner. The most common side effect is diarrhea.

• Lower phosphate levels in adults with chronic kidney disease (CKD) on dialysis who haven't responded well to or can't take phosphate binders

• Diarrhea (43-53%)

• Diarrhea

Ibsrela (tenapanor) is used to treat adults with irritable bowel syndrome with constipation (IBS-C). This medication belongs to the drug class called sodium/hydrogen exchanger 3 (NHE3) inhibitors. Ibsrela (tenapanor) is a tablet that's taken by mouth twice per day. There aren't many side effects, but the most common is diarrhea. Other side effects include bloating, gas, and dizziness.

• Irritable bowel syndrome with constipation (IBS-C) in adults

• Diarrhea (16%)
• Stomach bloating (3%)
• Gas (3%)
• Dizziness (2%)

• Serious dehydration in children
• Diarrhea