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Urispas vs. Nitrofurantoin

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Flavoxate (Urispas) and Nitrofurantoin (Macrobid) are both used to address urinary issues, but they serve different purposes and belong to different drug classes. Flavoxate, an anticholinergic and antispasmodic, helps relieve urinary symptoms like painful urination and bladder control issues but does not treat the underlying infection. It must be taken 3 to 4 times a day and is not recommended for people over 65. On the other hand, Nitrofurantoin, a nitrofuran antibiotic, treats and prevents urinary tract infections (UTIs) by killing bacteria in the urinary tract. The capsule form is typically taken twice a day with food and the oral suspension form is taken four times daily with food. While Flavoxate can cause drowsiness and blurred vision, Nitrofurantoin may turn your urine dark yellow or brown and can cause nausea and headaches. Nitrofurantoin is also not suitable for people with severe liver or kidney problems and should be avoided in the last weeks of pregnancy. Both medications have generic versions available, making them more affordable options.

Flavoxate

 

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Nitrofurantoin

(Macrobid)

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Summary for Urispas

Prescription only

Flavoxate treats urinary symptoms that you experience when you have a urinary or prostate infection. It cannot cure the infection on its own, but it can be used together with an antibiotic for treatment of an infection.

Indications for Urispas

  • Relieves urinary symptoms, such as painful urination, urinary urgency, frequency, loss of bladder control, frequent urination at night, and lower stomach pain, that you experience with urinary and prostate infections

Pros and Cons for Urispas

Pros

  • Works quickly (in 55 minutes) to relieve your urinary symptoms
  • Available as a lower-cost, generic medication

Cons

  • Only treats your urinary symptoms (not your infection), so it must be taken with another medication to treat your urinary or prostate infection
  • Taken 3 to 4 times per day
  • Generally not recommended in people 65 years and older
  • Cannot be used for people with active bleeding in their stomach
  • Hasn’t been studied in children less than 12 years old so it’s unclear if it’s safe or even works for them

Warnings for Urispas

  • Changes to your vision

Summary for Nitrofurantoin

Prescription only

Nitrofurantoin (Macrobid) is an antibiotic used to treat or prevent a urinary tract infection (UTI). Some side effects include nausea, headache, and gas. It can also make your urine turn dark yellow or brown. Nitrofurantoin (Macrobid) doesn't have many interactions with other medications. There's a lower-cost generic version of nitrofurantoin (Macrobid) available.

Indications for Nitrofurantoin

  • Treatment or prevention of urinary tract infections

Pros and Cons for Nitrofurantoin

Pros

Cons

  • Might need to take up to four times a day (depending on the formulation)
  • Can interact with certain types of antacids, travel vaccines, and lab tests
  • Can harm your lungs, liver, and nerves if taken for a long period of time

Common Side Effects for Nitrofurantoin

  • Nausea (8%)
  • Headache (6%)
  • Gas (2%)

Warnings for Nitrofurantoin

  • Lung damage
  • Liver damage
  • Nerve damage (neuropathy)
  • Breakdown of red blood cells (hemolytic anemia)
  • Severe diarrhea

Prices with our coupons for Urispas vs. Nitrofurantoin

Price Card Drug Icon
Flavoxate30 tablets / 100mg
$21.69$49.29
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Price Card Drug Icon
Nitrofurantoin14 capsules / 100mg
$15.23$46.35
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