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Tyenne vs. Actemra

Tyenne (tocilizumab or tocilizumab-aazg) is a biologic medication and a biosimilar to Actemra (tocilizumab). It helps lower inflammation in certain autoimmune conditions like rheumatoid arthritis and juvenile idiopathic arthritis. It's also FDA approved to treat other conditions, including giant cell arteritis and COVID-19. Tyenne (tocilizumab) is given as an injection either under the skin or into a vein, depending on your condition. Common side effects include upper respiratory infections, headache, and injection‑site reactions.

• Moderate-to-severe rheumatoid arthritis (RA) - adults
• Giant cell arteritis (GCA) - adults
• Polyarticular juvenile idiopathic arthritis (PJIA) - adults and children 2 years and older
• Systemic juvenile idiopathic arthritis (SJIA) - adults and children 2 years and older
• Cytokine release syndrome (CRS) - adults and children 2 years and older
• COVID-19 infection - adults

• Upper respiratory tract infections (up to 7%)
• Common cold symptoms (up to 7%)
• Headache (up to 7%)
• High blood pressure (up to 6%)
• Higher liver enzymes (up to 6%)
• Injections-site reactions

^{*The side effects listed above were reported in clinical trials where IV Actemra was used to treat rheumatoid arthritis.}

• Serious infections
• Tears in the stomach or intestines
• Liver problems
• Low blood cell counts
• High cholesterol and triglycerides
• Cancer
• Severe allergic reactions
• Nerve problems
• Vaccines

Actemra (tocilizumab) is an interleukin-6 (IL-6) receptor antagonist. It treats several inflammatory conditions in children and adults, including rheumatoid arthritis. It works by blocking IL-6, a chemical released by the immune system that causes inflammation and fever. Actemra (tocilizumab) is given as an injection (either through the veins or under the skin), typically weekly or every few weeks, depending on the condition you're taking it treat. Side effects include a higher risk of infections and headache.

• Moderate-to-severe rheumatoid arthritis (RA) - adults
• Giant cell arteritis (GCA) - adults
• Systemic sclerosis-associated interstitial lung disease (SSc-ILD) - adults
• Polyarticular juvenile idiopathic arthritis (PJIA) - adults and children 2 years and older
• Systemic juvenile idiopathic arthritis (SJIA) - adults and children 2 years and older
• Cytokine release syndrome (CRS) - adults and children 2 years and older
• COVID-19 infection - adults and children 2 years and older

• Upper respiratory tract infections (up to 7%)
• Headache (up to 7%)
• High blood pressure (up to 6%)
• Higher liver enzymes (up to 6%)

Note: The side effects you experience might differ depending on why you're taking Actemra (tocilizumab) and whether you're receive it IV or SC.

• Risk of serious infections
• Stomach tears and blockage
• Worsening liver problems and risk of liver failure
• Severe allergic reactions
• Lower white blood cell (WBC) and platelet counts
• High cholesterol
• Vaccines