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Compare Dayquil vs. Alka-Seltzer Plus Severe Cold And Cough

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Acetaminophen/dextromethorphan/phenylephrine (Dayquil) and aspirin/chlorpheniramine/dextromethorphan/phenylephrine (Alka-Seltzer Plus Severe Cold and Cough) are both over-the-counter medications used to relieve symptoms of the common cold and flu, such as cough, congestion, and minor aches. Both medications contain dextromethorphan as a cough suppressant and phenylephrine as a decongestant. However, they have some important differences. Dayquil includes acetaminophen, an analgesic, while Alka-Seltzer Plus Severe Cold and Cough contains aspirin, a nonsteroidal anti-inflammatory drug (NSAID), and chlorpheniramine, an antihistamine. Dayquil is available in pill and liquid forms, while Alka-Seltzer Plus Severe Cold and Cough comes as effervescent tablets that dissolve in water. Dayquil may cause stomach upset and nervousness, while Alka-Seltzer Plus Severe Cold and Cough can cause sleepiness, dizziness, and dry mouth. Both medications should not be taken with monoamine oxidase inhibitors (MAOIs) or other medications containing similar ingredients to avoid serious side effects.

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