Head-to-head comparisons of medication uses, side effects, warnings, and more.
Acetaminophen/dextromethorphan/phenylephrine (Dayquil) and aspirin/chlorpheniramine/dextromethorphan/phenylephrine (Alka-Seltzer Plus Severe Cold and Cough) are both over-the-counter medications used to relieve symptoms of the common cold and flu, such as cough, congestion, and minor aches. Both medications contain dextromethorphan as a cough suppressant and phenylephrine as a decongestant. However, they have some important differences. Dayquil includes acetaminophen, an analgesic, while Alka-Seltzer Plus Severe Cold and Cough contains aspirin, a nonsteroidal anti-inflammatory drug (NSAID), and chlorpheniramine, an antihistamine. Dayquil is available in pill and liquid forms, while Alka-Seltzer Plus Severe Cold and Cough comes as effervescent tablets that dissolve in water. Dayquil may cause stomach upset and nervousness, while Alka-Seltzer Plus Severe Cold and Cough can cause sleepiness, dizziness, and dry mouth. Both medications should not be taken with monoamine oxidase inhibitors (MAOIs) or other medications containing similar ingredients to avoid serious side effects.
Dayquil Cold and Flu is a combination of three active ingredients: acetaminophen (an analgesic), dextromethorphan (a cough suppressant), and phenylephrine (a decongestant). Dayquil Cold and Flu helps treat symptoms from the common cold and flu in adults and children. It can relieve stuffy nose, cough, sore throat, headache, aches, and fever. Besides Dayquil Cold and Flu, this medication is available under many other brand names and as a generic. It's available as pills and a liquid that's typically taken every 4 hours. Side effects aren't common but can include stomach upset and nervousness.
Alka-Seltzer Plus Severe Cold And Cough is a combination of four medications: aspirin (a nonsteroidal anti-inflammatory drug or NSAID), chlorpheniramine (an antihistamine), dextromethorphan (a cough suppressant), and phenylephrine (a decongestant). It's used to treat symptoms from the common cold (e.g., cough, congestion, pain, headache). This medication is available over the counter for adults and children ages 12 years and older. It comes as effervescent tablets that you dissolve in water before you drink the mixture. The dosage can be repeated every 4 hours if needed. Side effects might include making you sleepy or dizzy.
Short-term relief of symptoms from the common cold:
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