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Orilissa vs. Myfembree

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Orilissa (elagolix) and Myfembree (relugolix / estradiol / norethindrone) are both medications used to relieve pain from endometriosis, but they belong to different medication classes. Orilissa is a gonadotropin-releasing hormone (GnRH) antagonist, while Myfembree combines a GnRH antagonist with estrogen and progestin. Orilissa is specifically FDA-approved for moderate-to-severe pain caused by endometriosis, whereas Myfembree is approved for both endometriosis pain and heavy menstrual bleeding related to uterine fibroids. Orilissa is taken once or twice daily, while Myfembree is taken once daily. Common side effects of Orilissa include hot flashes and headaches. Myfembree can cause similar side effects, but it also has a risk of blood clots, heart attacks, and strokes. Both medications can lead to bone loss with long-term use, so they are typically limited to a maximum of 2 years of treatment. Additionally, both medications can interact with hormonal birth control and are not recommended during pregnancy, so it's important to use non-hormonal birth control while taking either medication.

Orilissa

(elagolix)

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Myfembree

 

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Summary for Orilissa

Prescription only

Orilissa (elagolix) is a hormone-free medication that's used to help manage moderate-to-severe pain caused by endometriosis. It belongs to a drug class called gonadotropin-releasing hormone (GnRH) antagonists. The medication is a tablet that's typically taken by mouth once or twice a day. Common side effects include hot flashes and headaches. It might also raise your risk of mood changes, and very rarely, suicidal thoughts. Orilissa (elagolix) can interact with many medications, including birth control pills.

Indications for Orilissa

Pros and Cons for Orilissa

Pros

  • Helps relieve pain due to endometriosis
  • Doesn't contain hormones
  • Taken once or twice a day

Cons

  • Might not feel pain relief right away (can take a month or longer)
  • Risk for bone loss with long-term treatment (can only take the medication for a set amount of time)
  • Approved for adults only

Common Side Effects for Orilissa

  • Hot flash (24-46%)
  • Headache (17-20%)
  • Nausea (11-16%)
  • Trouble sleeping (6-9%)
  • Missing a menstrual period (4-7%)
  • Mood swings (5-6%)
  • Depressed mood (3-6%)
  • Anxiety (3-5%)
  • Joint pain (3-5%)

Warnings for Orilissa

  • Bone loss
  • Change in menstrual bleeding pattern and effect on recognizing pregnancy
  • Suicidal thoughts or behavior or worsened mood problems
  • Liver damage
  • Interactions with hormonal birth control
  • Risk of harm to unborn baby

Summary for Myfembree

Prescription only

Myfembree is a combination medication containing relugolix, estradiol, and norethindrone. It's used to manage heavy menstrual bleeding related to uterine fibroids. This medication can also help relieve pain from endometriosis. Myfembree is approved for use in women who haven't reached menopause and is a tablet that's taken once daily. Common Myfembree side effects include hot flashes and headaches.

Indications for Myfembree

  • Heavy menstrual bleeding related to uterine fibroids in women who haven't reached menopause
  • Moderate-to-severe pain related to endometriosis in women who haven't reached menopause

Pros and Cons for Myfembree

Pros

  • Only taken once a day
  • Can also provide relief from pain and symptoms related to uterine fibroids like pelvic pressure or discomfort
  • Can relieve different types of pain from endometriosis (e.g., pain during your menstrual period, pelvic pain unrelated to your period)

Cons

  • Might have irregular menstrual bleeding patterns
  • Can raise the risk of blood clots, heart attacks, or strokes
  • Recommended to take for a maximum of 2 years because of the risk for bone loss

Common Side Effects for Myfembree

Uterine fibroids:

  • Hot flashes, a lot of sweating, or night sweats (11%)
  • New or worsening high blood pressure (7%)
  • Unusual or irregular vaginal bleeding (6%)
  • Hair loss or hair thinning (4%)

Endometriosis:

  • Headache (33%)
  • Hot flashes, a lot of sweating, or night sweats (13%)
  • Mood problems or mood swings (9%)
  • Unusual vaginal bleeding (7%)
  • Nausea (6%)

Warnings for Myfembree

  • Blood clots, heart attacks, and strokes
  • Bone loss
  • Can't take if you have certain hormone-sensitive cancers
  • Change in menstrual bleeding patterns
  • Not able to recognize pregnancy and risk of early pregnancy loss
  • Depression, mood changes, and suicidal behavior
  • Liver or gallbladder problems
  • Risk of your fibroid coming out into the vagina
  • Changes to certain lab test results

Prices with our coupons for Orilissa vs. Myfembree

Price Card Drug Icon
Orilissa1 dose pack / 28 tablets of 150mg
$1,232.38$1,589.72
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Myfembree28 tablets / 40mg/1mg/0.5mg
$1,276.39$1,655.57
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