Omegaven
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SMOFlipid
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Summary for Omegaven
Omegaven is an intravenous (IV) lipid supplement that's made with fish oil. It's a source of calories and fatty acids for children with liver problems caused by long-term parenteral nutrition (or TPN). This condition is called parenteral nutrition-associated cholestasis (PNAC). Omegaven is given as an infusion into the vein over 8 to 24 hours, depending on your child's needs. Side effects include vomiting and restlessness.
Indications for Omegaven
- Lipid supplement for children with liver problems from long-term nutrition through the vein (also called parenteral nutrition-associated cholestasis or PNAC)
Pros and Cons for Omegaven
Pros
- Helps provide a source of calories and essential fats to children with PNAC
- Shown to improve PNAC by lowering inflammation
- Possible to give at home
Cons
- Not a good option if your child has an allergy to fish or egg, since it contains fish oil and egg proteins
- Not used to prevent PNAC
- Not approved for use in adults
Common Side Effects for Omegaven
- Vomiting (46%)
- Irritated or restless behavior (35%)
- Low heart rate (35%)
- Episodes of pauses in breathing (apnea; 20%)
- Viral infection (16%)
- Skin redness (12%)
Warnings for Omegaven
- Risk of serious harm if it's infused too fast
- Serious allergic reactions
- Risk of infections
- Problems related to receiving too much lipids (fat overload syndrome)
- High triglyceride (fat) levels
- Aluminum toxicity
Summary for Smoflipid
SMOFlipid is the first and only injectable lipid supplement that contains 4 different kinds of fats: soybean oil, medium chain triglycerides, olive oil, and fish oil. It's for people on total parenteral nutrition (TPN) who aren't able to eat or drink. It can be used by children, including babies who are born before their due date, as well as adults. Some common side effects caused by SMOFlipid include nausea, vomiting, and infections.
Indications for Smoflipid
- Lipid supplement for people on total parenteral nutrition (TPN) who can't eat or drink
Pros and Cons for Smoflipid
Pros
- Well-balanced source of fat since it contains four different types of fat
- Works well to provide a source of calories and essential fatty acids to people who can't eat or drink
- Appears to be safer compared to other available lipid supplements
- Can be used in people of all ages
Cons
- Has risk of liver problems
- Brand name only, which can be expensive
- Only given by injection through the veins
- Might raise your risk of infection
Common Side Effects for Smoflipid
Adults:
- Nausea (9%)
- Vomiting (7%)
- High blood sugar (5%)
Children:
- Low red blood cell count (18%)
- Vomiting (9%)
- Liver damage (6%)
- Infection (6%)
Warnings for Smoflipid
- Liver problems
- Serious allergic reactions
- Risk of infections
- Too much IV lipids (fat overload syndrome)
- High triglyceride (fat) levels
- Aluminum toxicity
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