Lokelma
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Sodium polystyrene sulfonate
(SPS)
Get free couponsSummary for Lokelma
Lokelma, also known by its generic name sodium zirconium cyclosilicate, is used to treat adults with high potassium levels (hyperkalemia). It belongs to the class of medications called potassium binders. The medication comes as a packet of powder that's mixed with 3 tablespoons of water. Dosing is usually adjusted based on your blood potassium levels, but after the first two days of treatment, it's typically taken by mouth once a day. The most common side effect is swelling from too much fluid.
Indications for Lokelma
- High potassium levels (hyperkalemia) in adults
Pros and Cons for Lokelma
Pros
- Works well to lower potassium levels
- Generally well tolerated with few side effects
- Not absorbed in your body, so it's expected to be safe in pregnancy and breastfeeding
Cons
- Can't be used to quickly lower high potassium level in emergency situations
- Only available as a powder that needs to be mixed with water
- Not known whether it's safe for use in children
Common Side Effects for Lokelma
- Swelling in the hands, legs, and feet (up to 16%)
Warnings for Lokelma
- Worsening of stomach problems
- Swelling
- Low potassium level (people on hemodialysis)
Summary for Kayexalate
Sodium polystyrene sulfonate (more commonly known by its brand name, Kayexalate) is a medication used to treat high potassium levels (hyperkalemia). Sodium polystyrene sulfonate (SPS) is available as a liquid suspension that's given orally (by mouth) or as an enema. It also comes as a powder that needs to be mixed into a suspension. Sodium polystyrene sulfonate (SPS) is typically taken 1 to 4 times a day, but make sure to follow your provider's instructions. This medication can cause low appetite and stomach-related side effects (e.g., nausea, vomiting, constipation or diarrhea).
Indications for Kayexalate
- High potassium levels (hyperkalemia)
Pros and Cons for Kayexalate
Pros
- Option for taking by mouth or as an enema
- Powder form can be stored at room temperature
- Available in a lower-cost, generic form
Cons
- Not a first-choice option for lowering potassium levels
- Must space out at least 3 hours from other oral (by mouth) medications
- Not a good choice for people with gut-movement problems
Common Side Effects for Kayexalate
- Low appetite
- Nausea
- Vomiting
- Constipation
- Diarrhea
Warnings for Kayexalate
- Serious stomach and intestinal side effects (intestinal necrosis)
- Low potassium, magnesium, and calcium levels
- Swelling
- Separate from other medications
- Choking risk
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