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Klisyri vs. Fluorouracil

Klisyri (tirbanibulin) is an ointment used for actinic keratosis on the face or scalp. It's FDA approved for adults only. The medication works as a microtubule inhibitor to treat these rough, scaly skin patches caused by long-term sun exposure. Klisyri (tirbanibulin) is applied to the affected skin once a day for 5 days in a row. Side effects include skin redness, skin flaking or scaling, and skin crusting.

• Actinic keratosis on the face or scalp of adults

• Skin redness
• Skin flaking or scaling
• Skin crusting
• Swelling of the skin
• Itching where applied
• Pain where applied

• Eye irritation if it gets near or in your eye
• Skin reactions where applied

Fluorouracil (Efudex) topical is an antimetabolite. It's available as 5% topical cream and solution, and as 2% solution. Both strengths can treat actinic keratosis, a precancerous skin condition caused by exposure to ultraviolet (UV) light over time. But only fluorouracil 5% is approved to treat basal cell carcinoma, a type of skin cancer. Fluorouracil (Efudex) topical is applied directly on the affected area(s) twice daily for 2 to 6 weeks, depending on what condition you're being treated for. Side effects of this medication can include skin burning, crusting, and irritation.

• Actinic (or solar) keratosis (scaly pre-cancerous spot or growth on the skin) in adults
• Basal cell carcinoma (certain type of skin cancer) in adults

• Crusting of the skin
• Stinging or burning feeling of the skin
• Itchiness
• Soreness on the skin
• Scarring

• Avoid sensitive skin areas
• Don't cover skin areas after application
• Sunburn
• Harm to unborn baby
• Rare toxicity reaction