Imkeldi vs. Imatinib for Leukemia and Soft Tissue Sarcoma: Important Differences and Potential Risks.

Imkeldi

(imatinib)

Imatinib

(Gleevec)

Summary for Imkeldi

Prescription only

Imkeldi (imatinib) is an oral solution that's FDA approved to treat certain blood cancers and other rare cancers in adults and some children. Because it comes as a liquid, it can be a good option if you have trouble swallowing tablets. Depending on the condition being treated, you take it by mouth once or twice a day. Common side effects include fluid buildup, nausea, muscle cramps, and diarrhea.

Indications for Imkeldi

Certain blood cancers

Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML)
Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL)
Myelodysplastic / myeloproliferative neoplasms (MDS/MPD) with certain genetic mutations
Aggressive systemic mastocytosis (ASM)
Hypereosinophilic syndrome (HES) or chronic eosinophilic leukemia (CEL)

Certain skin cancer

Dermatofibrosarcoma protuberans (DFSP)

Certain tumors in the digestive tract

Gastrointestinal stromal tumors (GIST)

Pros and Cons for Imkeldi

Pros

Treats several different types of cancer
Liquid form can help if you have trouble swallowing tablets
Approved for adults and some children, depending on the condition

Cons

Many medication and food interactions
Regular blood tests are usually needed
Swelling, nausea, and diarrhea are common

Common Side Effects for Imkeldi

Newly diagnosed CML

Fluid buildup or swelling (62%)
Nausea (50%)
Muscle cramps (49%)
Bone or muscle pain (47%)
Diarrhea (45%)
Rash (40%)
Tiredness (39%)
Stomach pain (37%)
Common cold symptoms (31%)
Joint pain (31%)

MDS/MPD

Nausea (57%)
Diarrhea (43%)
Muscle cramps (43%)

DFSP

Nausea (42%)
Tiredness (42%)
Swelling around the eyes (33%)
Swelling in the arms or legs (33%)
Diarrhea (25%)
Vomiting (25%)
Rash (25%)
More tears (25%)
Low red blood cell count (25%)

GIST

Fluid buildup or swelling (77%)
Tiredness (69%)
Nausea (58%)
Stomach pain or cramping (57%)
Diarrhea (56%)
Rash or skin peeling (38%)
Vomiting (37%)
Muscle pain (32%)
Low red blood cell count (32%)
Reduced appetite (31%)

Note: Side effect rates differed across studies and conditions.

Warnings for Imkeldi

Fluid buildup and swelling
Low blood cell counts
Heart failure
Liver problems
Bleeding
Stomach problems
Heart problems in certain conditions
Serious skin reactions
Low thyroid hormone levels
Harm to unborn baby
Slowed growth in children
Tumor lysis syndrome
Kidney problems

Summary for Imatinib

Prescription only

Imatinib (Gleevec) is an oral medication used to treat several types of blood cancers and other rare cancers in adults and some children. Depending on the condition being treated, you take it by mouth once or twice a day. Common side effects include fluid buildup, nausea, muscle cramps, and diarrhea.

Indications for Imatinib

Certain blood cancers

Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML)
Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL)
Myelodysplastic / myeloproliferative neoplasms (MDS/MPD) with certain genetic mutations
Aggressive systemic mastocytosis (ASM)
Hypereosinophilic syndrome (HES) or chronic eosinophilic leukemia (CEL)

Certain skin cancer

Dermatofibrosarcoma protuberans (DFSP)

Certain tumors in the digestive tract

Gastrointestinal stromal tumors (GIST)

Pros and Cons for Imatinib

Pros

Treats several different types of cancer
Tablet taken by mouth
Approved for adults and some children, depending on the condition

Cons

Can cause liver problems and low blood cell counts
Not safe during pregnancy
Interacts with many medications

Common Side Effects for Imatinib

Newly diagnosed CML

Fluid buildup or swelling (62%)
Nausea (50%)
Muscle cramps (49%)
Bone or muscle pain (47%)
Diarrhea (45%)
Rash (40%)
Tiredness (39%)
Stomach pain (37%)
Common cold symptoms (31%)
Joint pain (31%)

MDS/MPD

Nausea (57%)
Diarrhea (43%)
Muscle cramps (43%)

DFSP

Nausea (42%)
Tiredness (42%)
Swelling around the eyes (33%)
Swelling in the arms or legs (33%)
Diarrhea (25%)
Vomiting (25%)
Rash (25%)
More tears (25%)
Low red blood cell count (25%)

GIST

Fluid buildup or swelling (77%)
Tiredness (69%)
Nausea (58%)
Stomach pain or cramping (57%)
Diarrhea (56%)
Rash or skin peeling (38%)
Vomiting (37%)
Muscle pain (32%)
Low red blood cell count (32%)
Reduced appetite (31%)

Note: Side effect rates differed across studies and conditions.

Warnings for Imatinib

Fluid buildup and swelling
Low blood cell counts
Heart failure
Liver problems
Bleeding
Stomach problems
Heart problems in certain conditions
Serious skin reactions
Low thyroid hormone levels
Harm to unborn baby
Slowed growth in children
Tumor lysis syndrome
Kidney problems

Prices with our coupons for Imkeldi vs. Imatinib

Imkeldi1 bottle / 140ml of 80mg/ml

$2,329.93$2,706.56

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Imatinib30 tablets / 400mg

$100.29$10,931.98

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Imkeldi vs. Imatinib

Imkeldi

Imatinib

Summary for Imkeldi

Indications for Imkeldi

Pros and Cons for Imkeldi

Pros

Cons

Common Side Effects for Imkeldi

Warnings for Imkeldi

Summary for Imatinib

Indications for Imatinib

Pros and Cons for Imatinib

Pros

Cons

Common Side Effects for Imatinib

Warnings for Imatinib

Prices with our coupons for Imkeldi vs. Imatinib

Browse medications by letter

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Imkeldi

Imatinib

Summary for Imkeldi

Indications for Imkeldi

Pros and Cons for Imkeldi

Pros

Cons

Common Side Effects for Imkeldi

Warnings for Imkeldi

Summary for Imatinib

Indications for Imatinib

Pros and Cons for Imatinib

Pros

Cons

Common Side Effects for Imatinib

Warnings for Imatinib