Key takeaways
Felodipine ER and Zestoretic (lisinopril / hydrochlorothiazide) are both medications used to treat high blood pressure in adults. However, they belong to different medication classes. Felodipine ER is a calcium channel blocker (CCB) that works by relaxing blood vessels, while Zestoretic is a combination of an angiotensin-converting enzyme (ACE) inhibitor (lisinopril) and a diuretic (hydrochlorothiazide), which lowers blood pressure by relaxing blood vessels and removing extra fluid from the body. Felodipine ER is taken as a single medication, typically once daily, and is available as a generic. Zestoretic is also taken once daily and is available as a brand-name and generic combination pill. Common side effects of felodipine ER include swelling, headache, and flushing, while Zestoretic can cause dizziness, headache, and cough. Both medications can cause low blood pressure, but Zestoretic has additional risks like angioedema and kidney problems. Felodipine ER should not be taken with grapefruit, and Zestoretic should be used cautiously with certain other medications like nonsteroidal anti-inflammatory drugs (NSAIDs).
