Eliglustat vs. Miglustat for Lysosomal Storage Disease: Important Differences and Potential Risks.

Cerdelga

(eliglustat)

Miglustat

(Zavesca)

Summary for Eliglustat

Prescription only

Cerdelga (eliglustat) is a medication that belongs to a drug class known as glucosylceramide synthase inhibitors. This medication is FDA-approved as long-term treatment for certain adults with a rare genetic condition called Gaucher disease type 1 (GD1). Cerdelga (eliglustat) is a capsule that's taken by mouth. Side effects can include fatigue, headache, and nausea.

Indications for Eliglustat

Gaucher disease type 1 (GD1) in certain adults

Pros and Cons for Eliglustat

Pros

First-choice treatment option in most adults with GD1
Can take with or without food
Taken by mouth, so it doesn’t require an IV or port like enzyme replacement therapy (ERT)
More convenient than ERT since you don't need frequent trips to the infusion center

Cons

Requires genetic testing before you start treatment
Has many drug interactions (such as with certain antidepressants, antibiotics, and anti-seizure medications)
Might not be able to use if you have certain liver, kidney, or heart problems because of the risk for serious side effects
Not for use in children because it hasn’t been studied

Common Side Effects for Eliglustat

Fatigue (14%)
Headache (13%)
Nausea (12%)
Diarrhea (12%)
Back pain (12%)
Pain in arm or leg (11%)
Upper stomach pain (10%)

Warnings for Eliglustat

Heart rhythm problems

Summary for Miglustat

Prescription only

Miglustat (Zavesca) is an oral medication used to treat adults with mild to moderate type 1 Gaucher disease. It’s only used in people who can’t receive enzyme replacement therapy (ERT). Miglustat (Zavesca) is available as a generic medication so it might be less expensive than other branded medications approved for this condition.

Indications for Miglustat

Mild to moderate type 1 Gaucher disease in adults

Pros and Cons for Miglustat

Pros

Available as a lower-cost generic medication
More convenient than frequent trips to the infusion center for ERT
Is available as an oral medication, so it doesn’t require an IV or port compared to ERT
Doesn't require genetic testing before starting like Cerdelga (eliglustat)

Cons

Diarrhea and tremors are very common side effects
Is taken three times a day in most adults
Not for use in children or teenagers with type 1 Gaucher disease
Can only be used if you can’t receive ERT

Common Side Effects for Miglustat

Diarrhea (89-100%)
Weight loss (39-67%)
Stomach pain (18-67%)
Passing gas (29-50%)
Tremor (11-30%)
Headache (21-22%)
Nausea (8-22%)
Weakness (17%)
Vision problems (<17%)
Vomiting (4-11%)
Leg cramps (4-11%)

Warnings for Miglustat

Nerve problems (peripheral neuropathy)
Tremors
Diarrhea and weight loss
Lowering of platelet count

Prices with our coupons for Eliglustat vs. Miglustat

Cerdelga56 capsules / 84mg

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Miglustat1 carton / 90 capsules of 100mg

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Eliglustat vs. Miglustat

Cerdelga

Miglustat

Summary for Eliglustat

Indications for Eliglustat

Pros and Cons for Eliglustat

Pros

Cons

Common Side Effects for Eliglustat

Warnings for Eliglustat

Summary for Miglustat

Indications for Miglustat

Pros and Cons for Miglustat

Pros

Cons

Common Side Effects for Miglustat

Warnings for Miglustat

Prices with our coupons for Eliglustat vs. Miglustat

Browse medications by letter

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Cerdelga

Miglustat

Summary for Eliglustat

Indications for Eliglustat

Pros and Cons for Eliglustat

Pros

Cons

Common Side Effects for Eliglustat

Warnings for Eliglustat

Summary for Miglustat

Indications for Miglustat

Pros and Cons for Miglustat

Pros

Cons

Common Side Effects for Miglustat

Warnings for Miglustat