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Compare Eliglustat vs. Miglustat

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Cerdelga (eliglustat)
    Miglustat (Zavesca)
  • Cerdelga (eliglustat)
    Miglustat (Zavesca)

  • Summary of Eliglustat vs. Miglustat

    Summary for Glucosylceramide synthase inhibitor
    Prescription only

    Cerdelga (eliglustat) is a medication that belongs to a drug class known as glucosylceramide synthase inhibitors. This medication is FDA-approved as long-term treatment for certain adults with a rare genetic condition called Gaucher disease type 1 (GD1). Cerdelga (eliglustat) is a capsule that's taken by mouth. Side effects can include fatigue, headache, and nausea.

    Summary for Glucosylceramide synthase inhibitor
    Prescription only

    Miglustat (Zavesca) is an oral medication used to treat adults with mild to moderate type 1 Gaucher disease. It’s only used in people who can’t receive enzyme replacement therapy (ERT). Miglustat (Zavesca) is available as a generic medication so it might be less expensive than other branded medications approved for this condition.

  • Indications of Eliglustat vs. Miglustat

    Indications for
    •Gaucher disease type 1 (GD1) in certain adults
    Indications for
    •Mild to moderate type 1 Gaucher disease in adults

  • Pros and Cons of Eliglustat vs. Miglustat

    Pros and Const for Glucosylceramide synthase inhibitor
    Pros
    •First-choice treatment option in most adults with GD1
    •Can take with or without food
    •Taken by mouth, so it doesn’t require an IV or port like enzyme replacement therapy (ERT)
    •More convenient than ERT since you don't need frequent trips to the infusion center
    Cons
    •Requires genetic testing before you start treatment
    •Has many drug interactions (such as with certain antidepressants, antibiotics, and anti-seizure medications)
    •Might not be able to use if you have certain liver, kidney, or heart problems because of the risk for serious side effects
    •Not for use in children because it hasn’t been studied
    Pros and Const for Glucosylceramide synthase inhibitor
    Pros
    •Available as a lower-cost generic medication
    •More convenient than frequent trips to the infusion center for ERT
    •Is available as an oral medication, so it doesn’t require an IV or port compared to ERT
    •Doesn't require genetic testing before starting like Cerdelga (eliglustat)
    Cons
    •Diarrhea and tremors are very common side effects
    •Is taken three times a day in most adults
    •Not for use in children or teenagers with type 1 Gaucher disease
    •Can only be used if you can’t receive ERT

  • Common Side Effects of Eliglustat vs. Miglustat

    Common Side Effects for
    •Fatigue (14%)
    •Headache (13%)
    •Nausea (12%)
    •Diarrhea (12%)
    •Back pain (12%)
    •Pain in arm or leg (11%)
    •Upper stomach pain (10%)
    Common Side Effects for
    •Diarrhea (89-100%)
    •Weight loss (39-67%)
    •Stomach pain (18-67%)
    •Passing gas (29-50%)
    •Tremor (11-30%)
    •Headache (21-22%)
    •Nausea (8-22%)
    •Weakness (17%)
    •Vision problems (<17%)
    •Vomiting (4-11%)
    •Leg cramps (4-11%)

  • Warnings of Eliglustat vs. Miglustat

    Common Side Effects for
    •Heart rhythm problems
    Common Side Effects for
    •Nerve problems (peripheral neuropathy)
    •Tremors
    •Diarrhea and weight loss
    •Lowering of platelet count

  • Prices with our coupons for Eliglustat vs. Miglustat

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    Learn more about Miglustat

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