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Chlorpheniramine vs. Diphenhydramine

Chlorpheniramine is an over-the-counter (OTC) antihistamine that treats allergy symptoms like sneezing, runny nose, and itchy throat. It works by blocking a chemical called histamine in our bodies. The medication is typically taken by mouth every 4 to 6 hours as needed, but there's an extended-release tablet that can be taken twice daily. Chlorpheniramine is available as a generic and many different brand-name products. Some side effects include drowsiness and dry mouth. It's generally considered safe to take during pregnancy.

Short-term relief of allergy symptoms:

• Sneezing
• Runny nose
• Itchy or watery eyes
• Itchy nose or throat

• Sleepiness
• Dizziness
• Constipation
• Blurry vision
• Dry mouth

• Sleepiness
• Worsening of medical conditions
• Accidental overdose

Diphenhydramine, also known by the brand name Benadryl, is an over-the-counter antihistamine used to relieve allergy or common cold symptoms in adults and children. It comes as pills and a liquid and is typically taken by mouth every 4 to 6 hours as needed. Because it can make you drowsy, some people also use it as a sleep aid at bedtime. Common side effects include sleepiness, dizziness, and dry mouth.

• Short-term relief of allergy or common cold symptoms (runny nose, sneezing, itchy nose or throat, and itchy or watery eyes) - people 6 years and older
• Occasional trouble sleeping - people 12 years and older

• Sleepiness
• Dizziness
• Constipation
• Blurry vision
• Dry mouth

• Sleepiness
• Accidental overdose
• Worsening of certain health problems