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Compare Ambrisentan vs. Bosentan

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Ambrisentan (Letairis)
    Bosentan (Tracleer)
  • Ambrisentan (Letairis)
    Bosentan (Tracleer)

  • Summary of Ambrisentan vs. Bosentan

    Summary for Endothelin receptor antagonist
    Prescription only

    Ambrisentan, also known by its brand name Letairis, is a medication used for pulmonary arterial hypertension (PAH), or high blood pressure in the blood vessels of the lungs. This medication is available as a lower-cost generic. The usual dose is one tablet daily. Ambrisentan (Letairis) is generally well-tolerated, though the most common side effect is swelling in the arms or legs. It also has a risk of causing severe and life-threatening harm to unborn babies, so the medication is only available through the Ambrisentan REMS program for people who can get pregnant.

    Summary for Endothelin receptor antagonist
    Prescription only

    Bosentan (Tracleer) improves your ability to exercise and slows worsening of pulmonary arterial hypertension (PAH), but it has several drug interactions and can cause liver damage.

  • Indications of Ambrisentan vs. Bosentan

    Indications for
    •Pulmonary arterial hypertension (PAH)
    Indications for
    •Pulmonary arterial hypertension (PAH)

  • Pros and Cons of Ambrisentan vs. Bosentan

    Pros and Const for Endothelin receptor antagonist
    Pros
    •Works well to slow the worsening of PAH and improve ability to breathe and exercise
    •Taken once a day with or without food
    •Generally mild or moderate side effects
    •Only available through a REMS program so that it's safe for people who can become pregnant
    Cons
    •Not a cure for PAH
    •Might affect sperm count and ability to have children in males
    •Females who can have children must use birth control and take a pregnancy test every month
    •Not for people with a lung problem called idiopathic pulmonary fibrosis (IPF) because of risk of harm
    Pros and Const for Endothelin receptor antagonist
    Pros
    •Helps slow down the worsening of PAH, so you are able to live longer with the condition
    •Can make it easier to breathe, exercise, and walk longer distances
    •Can be used in children as young as 3 years old
    •Also available as a dissolvable tablet
    •Safe to use if you have kidney problems
    Cons
    •If you are female, you will need to use birth control and take pregnancy tests every month.
    •Not all pharmacies can fill bosentan (Tracleer) prescriptions.
    •Can affect male sperm count and ability to have children
    •Can cause serious liver damage
    •Cannot be taken with cyclosporine A or glyburide

  • Common Side Effects of Ambrisentan vs. Bosentan

    Common Side Effects for
    •Swelling in the arms or legs (17%)
    •Stuffy nose (6%)
    •Flushing (4%)
    •Sinus infection or inflammation (3%)
    Common Side Effects for
    •Common cold symptoms or lung infection (22%)
    •Headache (15%)
    •Swelling due to fluid buildup (11%)
    •Chest pain (5%)
    •Fainting (5%)

  • Warnings of Ambrisentan vs. Bosentan

    Common Side Effects for
    •Not safe to use during pregnancy
    •Fluid buildup in the body
    •Anemia (low red blood cell count)
    Common Side Effects for
    •Liver damage
    •Birth defects
    •Fluid build-up
    •Serious lung disease
    •Low sperm count
    •Red blood cell effects

  • Prices with our coupons for Ambrisentan vs. Bosentan

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    Learn more about Bosentan

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