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Clindesse

Clindesse Side Effects

Kristianne Hannemann, PharmDDaisy Chau, PharmD
Reviewed by Kristianne Hannemann, PharmD, Daisy Chau, PharmD
Last reviewed on April 13, 2026

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Clindesse:

  • Vaginal yeast infection (14%)
  • Headache (7%)
  • Back pain (5%)
  • Constipation (2%)
  • Urinary tract infection (2%)

Cleocin and its generics:

  • Vaginal yeast infection (8-14%)
  • Vaginal irritation (4-6%)
  • Vaginal problems (3-5%)

Less Common Side Effects

Clindesse:

  • Rash
  • Diarrhea
  • Vomiting
  • Tiredness
  • Dizziness
  • Vaginal irritation

Cleocin and its generics:

  • Urinary tract infection
  • Stomach pain
  • Nausea
  • Vomiting
  • Constipation
  • Dizziness

Clindesse serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Severe allergic reactions: hives, rash, swelling of the lips or tongue, difficulty breathing
  • Severe diarrhea: stomach cramps, blood in your stool, watery diarrhea that doesn't go away, fever

Source: DailyMed

The following Clindesse side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

More common

Itching of the vagina or genital area

pain during sexual intercourse

thick, white vaginal discharge with no odor or with mild odor

Less common

Diarrhea

dizziness

headache

nausea or vomiting

stomach pain or cramps

Rare

Burning, itching, rash, redness, swelling or other signs of skin problems not present before use of this medicine

After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects:

Itching of the vagina or genital area

pain during sexual intercourse

thick, white vaginal discharge with no odor or with mild odor

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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