PDE5 inhibitor / 5-alpha-reductase inhibitor combinations are used to treat lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). These medications work by relaxing the muscles in your prostate and bladder and by reducing the size of your prostate. They help improve urine flow and reduce symptoms of BPH. They come in oral form, making them easy to take. An example of this combination is Entadfi (tadalafil / finasteride). You can take these medications to help manage your symptoms and improve your quality of life.