Microsomal triglyceride transfer protein (MTP) inhibitors are used to treat homozygous familial hypercholesterolemia (HoFH), a rare genetic condition that causes extremely high cholesterol levels. They work by blocking the action of the MTP enzyme, which is needed for the production of lipoproteins that carry cholesterol and triglycerides in your blood. These medications are available in oral form. An example of an MTP inhibitor is lomitapide (Juxtapid). You can take these medications to help manage your cholesterol levels.