CFTR potentiators are used to treat cystic fibrosis. These medications help the cystic fibrosis transmembrane conductance regulator (CFTR) protein work better, which controls the flow of salt and fluids in and out of cells. This reduces the thick mucus buildup in the lungs and other organs. CFTR potentiators are available in oral forms. Examples include ivacaftor (Kalydeco), lumacaftor / ivacaftor (Orkambi), tezacaftor / ivacaftor (Symdeko), and elexacaftor / tezacaftor / ivacaftor (Trikafta). You can take these medications as prescribed to help manage your condition.