BLyS-specific inhibitors are used to treat systemic lupus erythematosus (SLE) and lupus nephritis. These medications work by targeting and inhibiting B-lymphocyte stimulator (BLyS), a protein that plays a role in the survival and activity of B cells in the immune system. By reducing the activity of B cells, these medications help control an overactive immune response and lower inflammation. BLyS-specific inhibitors come in injectable forms. An example is Benlysta (belimumab), which is available as an injection that's given under the skin or as an intravenous infusion. You can choose the form that best fits your needs.