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Chlorzoxazone

Chlorzoxazone Side Effects

Allison Gourley, PharmDDaisy Chau, PharmD
Reviewed by Allison Gourley, PharmD, Daisy Chau, PharmD
Last reviewed on April 1, 2025

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Drowsiness
  • Dizziness
  • Feeling lightheaded
  • General discomfort or feeling ill

Less Common Side Effects

  • Rash or other skin reaction
  • Discolored urine
  • Overstimulation

Chlorzoxazone serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Liver damage: dark urine, yellowing of the skin or eyes, upper right stomach pain, loss of appetite
  • Severe allergic reaction: hives, rash, redness, itching, trouble breathing
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Source: DailyMed

The following Chlorzoxazone side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare

Bloody or black, tarry stools

clay-colored stools

constipation

cough

dark urine

decreased appetite

difficulty swallowing

dizziness

fast heartbeat

fever

headache

hives

itching

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

loss of appetite

nausea and vomiting

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

severe stomach pain

shortness of breath

skin rash

swelling of the feet or lower legs

tightness in the chest

unusual tiredness or weakness

vomiting of blood or material that looks like coffee grounds

wheezing

yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Diarrhea

difficult or troubled breathing

drowsiness

general feeling of discomfort or illness

headache

irregular, fast or slow, or shallow breathing

lightheadedness

nausea

pale or blue lips, fingernails, or skin

sluggishness

vomiting

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Rare

Bruising

large, flat, blue, or purplish patches in the skin

small red or purple spots on the skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Allison Gourley, PharmD, is a kidney and pancreas transplant pharmacist at a teaching hospital in the San Francisco Bay Area. When she’s not educating patients about their immunosuppressants, she's actively involved in transplant research.
Daisy Chau, PharmD
Reviewed by:
Daisy Chau, PharmD
Daisy Chau, PharmD, is the drug information pharmacist manager at GoodRx. She is licensed in California and has more than 6 years of experience working as a pharmacist in drug information.

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