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Injectable Wegovy (semaglutide) is a prescription glucagon-like peptide-1 (GLP-1) medication used for weight loss and long-term weight management. It is also approved to lower the risk of serious cardiovascular problems in adults with a larger body size and heart disease, as well as treatment for a liver disorder called metabolic dysfunction-associated steatohepatitis (MASH). It helps regulate appetite, leading to reduced calorie intake and weight loss. A higher-dose version, called Wegovy HD, is also available for people who need to achieve additional weight loss.

Semaglutide, the active ingredient in Wegovy and Wegovy HD injections, mimics the GLP-1 hormone, which helps regulate hunger and digestion. It slows how quickly food leaves the stomach and signals the brain to reduce appetite. This combination helps people eat less and lose weight over time.

On average, people lose about 14% of their starting weight over about a year of taking the 2.4 mg Wegovy (semaglutide) injection dose. Wegovy works best when combined with healthy lifestyle changes. Reaching and staying on the 2.4 mg recommended maintenance dose (or 1.7 mg dose if you can’t tolerate it) is important for sustained results, even if the amount of weight you lose each week begins to slow down. But if you’ve been using the 2.4 mg dose and need to lose more weight, the 7.2 mg dose (Wegovy HD) has been shown to provide about 19% weight loss on average.

Injectable Wegovy (semaglutide) is best known as a weight-loss medication. But it was also the first of its kind approved to reduce the risk of serious cardiovascular problems (heart attack, stroke, or cardiovascular death) in adults with heart disease who are considered overweight or obese. Injectable Wegovy is also the first GLP-1 approved for the treatment of a liver disorder called metabolic dysfunction-associated steatohepatitis (MASH).

Both Wegovy injections and Ozempic injections contain semaglutide, but they’re approved for different uses and come in different doses. Wegovy, which is available in higher doses than Ozempic, is approved for weight loss, reducing the risk of serious cardiovascular problems for adults with heart disease who are considered overweight or obese, and treatment of a liver condition known as MASH. Ozempic is approved for treating Type 2 diabetes, and for its heart and kidney protection benefits in certain people with diabetes.

Wegovy (semaglutide) and Wegovy HD injections are considered safe and effective for many people. They can cause side effects such as nausea and vomiting, diarrhea, and stomach pain that often improve over time. But Wegovy has also been linked to more serious side effects, such as pancreatitis, gallbladder problems, and gastroparesis. A healthcare professional will consider your health history and other factors to determine if Wegovy is a good fit for you.

Through GoodRx Care Direct, qualified patients can get Wegovy pens for $199 a month for the first two fills of 0.25 and 0.5 mg, plus necessary telehealth care and check-ins for $39 a month. Subsequent doses of Wegovy increase to $349 a month, and Wegovy HD costs $399 per month. The list price for Wegovy (semaglutide) is over $1,300 a month.

Wegovy HD is a new, higher-dose version of Wegovy injections. It contains 7.2 mg of semaglutide, which is 3 times the amount contained in the highest regular Wegovy dose (2.4 mg). If you’re not seeing enough weight loss on the 2.4 mg dose of Wegovy, your prescriber may recommend Wegovy HD.