Key takeaways:
Blujepa (gepotidacin) is a prescription antibiotic. It treats uncomplicated urinary tract infections (UTIs) in women and girls ages 12 years and older who weigh at least 88 lbs (40 kg). It can also treat uncomplicated gonorrhea in certain people.
Blujepa comes as 750 mg oral tablets. Blujepa’s FDA-approved dosage for UTIs is 2 tablets (1,500 mg) by mouth twice a day for 5 days. Adults and adolescents take the same dosage.
You shouldn’t take Blujepa if you have severe kidney or liver problems. This is also true if you take medications that significantly interact with Blujepa. Your healthcare team will be in charge of prescribing a UTI antibiotic that’s safe for you to take.
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Blujepa (gepotidacin) is a prescription antibiotic that treats uncomplicated urinary tract infections (UTIs). This is a common infection that happens when bacteria get into your urinary tract and begin to grow. If you’re experiencing symptoms of pain or burning while you pee and you have an otherwise healthy urinary tract, you might have one.
If you do have a UTI, you may need a 3- to 7-day course of antibiotics to treat the infection and prevent complications. Sometimes, though, a UTI can come back after you’ve finished your treatment. This may be due to antibiotic resistance, which means the bacteria are no longer responding well to the antibiotics meant to stop them.
That’s where Blujepa can make a difference. Blujepa is a first-in-class antibiotic that can treat simple UTIs. It’s meant for women and girls ages 12 years and older who weigh at least 88 lbs (40 kg). It’s helpful for those tough-to-treat bacteria.
Here, we’ll highlight typical Blujepa dosages for UTIs and when dose adjustments may be necessary.
What’s the typical Blujepa dosage for UTIs in adults?
Blujepa comes as 750 mg oral tablets. A typical Blujepa dosage for adult women weighing at least 88 lbs is 2 tablets (1,500 mg) by mouth 2 times a day (every 12 hours) for 5 days.
To reduce the chance of stomach upset, it’s recommended that you take Blujepa within 30 minutes of finishing a meal.
Good to know: As of December 2025, Blujepa is also FDA approved to treat gonorrhea of the urinary or genital tract in people ages 12 and older who weigh at least 88 lbs. The recommended Blujepa dosage for gonorrhea is 4 tablets (3,000 mg) taken by mouth, followed by another 4 tablets (3,000 mg) about 12 hours later.
What’s the typical Blujepa dosage for UTIs in children?
As with adults, a typical Blujepa dosage for UTIs in kids and adolescents is 2 tablets (1,500 mg) by mouth 2 times a day for 5 days. They should also take their doses after a meal to lessen stomach upset.
Remember: Blujepa is only approved for girls ages 12 and older who weigh at least 88 lbs. This is because Blujepa hasn’t been studied in children under 12 and people weighing less than 88 lbs. It hasn’t been studied for UTIs in boys or men, either.
Are there any dosage considerations for health conditions?
Yes, there are a few health conditions and situations that impact how well your body processes Blujepa. Some of these may impact how safe it is for you to take the antibiotic.
Kidney or liver problems
There are no dosage adjustments for people with mild to moderate kidney or liver problems. However, people with severe kidney issues — including those receiving dialysis — or severe liver issues may need to avoid Blujepa. This is because your kidneys and liver help clear Blujepa from your body.
If your body struggles to get rid of Blujepa, this can increase your risk for side effects, such as irregular heartbeat, dizziness, or stomach upset.
Interacting medications
Several medications can impact how Blujepa works in your body.
Blujepa is broken down by a liver enzyme (protein) called CYP3A4. You may need to avoid certain medications that are also broken down by CYP3A4 while taking Blujepa, such as cyclosporine (Neoral, Gengraf). These medications may compete with one another, leading to unpredictable levels in the body.
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Other medications may block the action of this enzyme. These are also known as CYP3A4 inhibitors. They can increase the amount of Blujepa in the body and raise the risk of side effects. A few examples of medications that may prompt your prescriber to choose a different antibiotic for you are:
Oral ketoconazole
Itraconazole (Sporanox)
Ritonavir and combination products that contain it, such as Kaletra and Paxlovid
Clarithromycin
Diltiazem (Cardizem, Tiazac)
On the other hand, some medications can make this enzyme more active. They decrease Blujepa levels in the body, potentially causing it to not work as well and leading to an undertreated UTI. You should avoid taking Blujepa with these medications and supplements:
Rifampin (Rifadin, Rimactane)
Carbamazepine (Tegretol)
Phenytoin (Dilantin)
Phenobarbital
St. John’s wort
Other interactions to consider
Blujepa can act like an acetylcholinesterase inhibitor. This means it increases the amount of a chemical in the body called acetylcholine. This, in turn, can boost the effects of other acetylcholinesterase inhibitors, such as donepezil (Aricept, Adlarity). On the flip side, Blujepa may work against the effects of anticholinergic medications, such as oxybutynin. Anticholinergics have the opposite effect and block the activity of acetylcholine.
Blujepa may also interact with medications that affect your heart rhythm. These medications can increase your risk of a side effect called QT prolongation. QT prolongation is a type of abnormal heartbeat.
What’s more, it’s important to note that Blujepa can affect the levels of digoxin (Lanoxin) in your blood. This may lead to more digoxin side effects. Let your prescriber know if you’re taking this medication, as they’ll likely want to monitor your digoxin levels more closely than usual.
It can be hard to know if you’re taking a medication that interacts with Blujepa. Your prescriber and pharmacist should screen for potential interactions before giving you the medication.
What happens if you miss a dose of Blujepa?
If you miss a dose of Blujepa, you should take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose. Don’t double any doses to make up for a missed one.
One missed dose shouldn't be a big deal. But missing several doses of Blujepa may impact the effectiveness of your treatment. If this happens to you, you should let your prescriber or pharmacist know. They may want to adjust your treatment plan.
If you need help remembering to take your medication, there are tools to help keep you on track. You can organize your doses into a pillbox or download medication reminder apps on your smartphone. You can even set simple reminders on devices you access frequently, such as your computer, tablet, or alarm clock.
What should you do if you take too much Blujepa?
Taking too much Blujepa could potentially lead to more side effects. If you accidentally take an extra dose, you may experience more diarrhea, nausea, and stomach pain.
It’s also possible to develop more serious symptoms. These may be more likely with a larger accidental ingestion. One of the rare-but-severe side effects of taking a large amount of Blujepa is QT prolongation. QT prolongation may feel like flutters in the chest and can result in fainting. It can also lead to life-threatening abnormal heart rhythms.
It can be scary if you think you or a loved one took too much medication. It’s important to contact a healthcare professional, such as your pharmacist, if you’re unsure what to do (or when you should take your next dose). You can also contact Poison Control online or at 1-800-222-1222.
If your symptoms feel severe, it’s better to call 911 or go to the nearest ER right away.
How to save on Blujepa
There are ways to save on Blujepa, which is only available as a brand-name medication.
Save with a copay savings card: If you have commercial insurance, you may be eligible to pay as little as $30 for Blujepa using a savings card from the manufacturer.
Save with GoodRx: Blujepa's price at certain pharmacies is as low as $772.64 with a free GoodRx discount.
The bottom line
Blujepa (gepotidacin) is an antibiotic that treats uncomplicated urinary tract infections (UTIs). Women and girls ages 12 and older weighing at least 88 lbs (40 kg) usually take two 750 mg tablets by mouth twice a day for 5 days. Blujepa can also treat uncomplicated gonorrhea in certain people in just two doses.
Some medications and health conditions can affect how Blujepa is broken down or removed from your body. If you have severe kidney or liver issues, or if you take certain interacting medications, you may need to avoid Blujepa. Be sure to tell your prescriber about any medications you’re taking before starting Blujepa. This includes any prescription medications, over-the-counter products, or dietary supplements. Let a healthcare professional know if you have any concerns while taking Blujepa.
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References
Bono, M. J., et al. (2025). Uncomplicated urinary tract infections. StatPearls.
Centers for Disease Control and Prevention. (2025). About antimicrobial resistance.
Čolović, M. B., et al. (2013). Acetylcholinesterase inhibitors: Pharmacology and toxicology. Current Neuropharmacology.
GlaxoSmithKline. (2025). Blujepa (gepotidacin) approved by US FDA as oral option for treatment of uncomplicated urogenital gonorrhoea (uGC).
GlaxoSmithKline. (2025). Blujepa (gepotidacin) tablets, for oral use [package insert].
McDonnell, A. M., et al. (2013). Basic review of the cytochrome P450 system. Journal of the Advanced Practitioner in Oncology.
Wagenlehner, F., et al. (2024). Oral gepotidacin versus nitrofurantoin in patients with uncomplicated urinary tract infection (EAGLE-2 and EAGLE-3): Two randomised, controlled, double-blind, double-dummy, phase 3, non-inferiority trials. The Lancet.
Watkins, R. R., et al. (2023). Gepotidacin: A novel, oral, ‘first-in-class’ triazaacenaphthylene antibiotic for the treatment of uncomplicated urinary tract infections and urogenital gonorrhoea. Journal of Antimicrobial Chemotherapy.
