The GoodRx Prescription Savings Blog

The latest updates on prescription drugs and ways to save from the GoodRx medical team

New Concentrated Humalog Pen Approved by the FDA

by The GoodRx Pharmacist on June 18, 2015 at 1:00 pm

A new strength of Humalog has been approved by the FDA: the Humalog U-200 KwikPen will offer another form of rapid-acting insulin to improve sugar control in adults with type 1 and type 2 diabetes.

What is rapid-acting insulin?

Rapid-acting insulin lowers blood sugar levels quickly; once injected it can take effect within 15 minutes and can last anywhere from three to five hours, continuing to lower your blood sugar after a meal.

Are there other rapid-acting insulins available?

Yes. Other examples of rapid-acting insulin include:

  • Humalog 100 units/mL (available in 3 mL and 10 mL vials, KwikPens, and cartridges)
  • NovoLog 100 units/mL (available in vials, FlexPens, and cartridges)
  • Apidra 100 units/mL (available in vials and SoloStar pens)

Is the Humalog U-200 KwikPen similar to any of the other rapid-acting insulins?

Yes. The Humalog U-200 KwikPen has the same active ingredient, insulin lispro, as the existing Humalog 100 units/mL vial, cartridge, and KwikPen.

How is the new Humalog U-200 different?

Although the Humalog U-200 KwikPen has the same active ingredient as Humalog 100 units/mL, the difference is in the strength. Humalog U-200 KwikPen has 200 units/mL, while the other Humalog pens and vials have 100 units/mL.

How will Humalog U-200 KwikPen be available?
Humalog U-200 KwikPen will be available as a disposable pre-filled 200 units/mL KwikPen.

How will Humalog U-200 be used?

The u-200 KwikPen is to be administered subcutaneously within 15 minutes before eating or right after eating a meal.

What are common side effects of Humalog?

The most common side effect associated with Humalog is hypoglycemia.

Is there anything unique about this FDA approval?

Yes. The Humalog U-200 KwikPen is the first FDA approval of a concentrated mealtime insulin. This medication has twice the amount of insulin lispro compared to the other Humalog 100 unit/mL formulations.

Is there an advantage to using Humalog 200 units/mL compared to Humalog 100 units/mL?

Yes. Some advantages include:

  • A longer-lasting pen, requiring fewer pen changes per month.
  • Same dose with a smaller amount of insulin to inject.
  • No dose conversion from the 100 units/mL to the 200 units/mL will be required.
  • You can dial the pen in single-unit increments, with a maximum of 60 units per injection.

Copyright ©2015 GoodRx, Inc.

This information is for informational purposes only and is not meant to be a substitute for professional medical advice, diagnosis or treatment. GoodRx is not offering advice, recommending or endorsing any specific prescription drug, pharmacy or other information on the site. GoodRx provides no warranty for any of the pricing data or other information. Please seek medical advice before starting, changing or terminating any medical treatment. Third party logos, trademarks, brand names and images contained on GoodRx.com are for demonstration purposes only and are owned by their respective rights holders, who are not affiliated with this Site.