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Promethazine DM is a combination of two medications.
Promethazine is a type of medication called phenothiazine. It works by blocking different chemicals in your brain and throughout your body that cause symptoms of allergies or nausea.
Dextromethorphan is a cough suppressant that works in the part of your brain that makes you cough. It lowers brain activity in that area, which makes it less likely for you to cough.