The length of time you can use prednisolone eye drops depends on why you're using them. For instance, you may need to use prednisolone eye drops for 2 to 6 weeks following cataract surgery. But if you're using them to help reduce pain and redness because of an eye infection, you'll likely only use them for about 1 week. It's recommended to use prednisolone eye drops for the shortest time needed. This helps lower the risk of serious or long-term side effects.