How long is it safe to use prednisolone eye drops?

The length of time you can use prednisolone eye drops depends on why you're using them. For instance, you may need to use prednisolone eye drops for 2 to 6 weeks following cataract surgery. But if you're using them to help reduce pain and redness because of an eye infection, you'll likely only use them for about 1 week. It's recommended to use prednisolone eye drops for the shortest time needed. This helps lower the risk of serious or long-term side effects.