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Celebrex (celecoxib) is a COX-2 selective nonsteroidal anti-inflammatory drug (NSAID). It works by blocking a protein called cyclooxygenase-2 (or COX-2) that's involved in causing pain and swelling. By blocking COX-2, this medication eases pain and swelling.
In contrast to most other NSAIDs, Celebrex (celecoxib) doesn't affect the COX-1 proteins protecting your stomach and gut. Blocking COX-2 rather than COX-1 is thought to explain why Celebrex (celecoxib) generally has a lower risk for stomach bleeding and ulcers.
