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Tnkase

tenecteplase
Used for Heart Attack
Used for Heart Attack

TNKase (tenecteplase) is an emergency medication used for the treatment of a heart attack. It's given as a quick injection into the vein by a healthcare provider in the hospital.

Reviewed by:
reviewer
Robert Chad Hakim, PharmD, BCCCP
reviewer
Kristianne Hannemann, PharmD
Last reviewed on May 18, 2022
BasicsFAQsInteractionsPricesMedicare
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What is TNKase (tenecteplase)?

How TNKase (tenecteplase) works

Drug Facts

Common BrandsTNKase
Drug ClassThrombolytic
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
faqs

Frequently asked questions about TNKase (tenecteplase)

What is TNKase (tenecteplase) used for?
TNKase (tenecteplase) is used for the treatment of a severe heart attack in people who aren't receiving percutaneous coronary intervention (PCI) (a procedure that opens up clogged blood vessels in the heart). Additionally, the American Heart Association (AHA) and American Stroke Association (ASA) suggest that TNKase (tenecteplase) can be used for the treatment of stroke caused by a blood clot in blood vessels in the brain (ischemic stroke). For stroke, TNKase (tenecteplase) can be used for people who aren't going to have a thrombectomy, which is a procedure where a healthcare provider removes a blood clot from a blood vessel.
How does TNKase (tenecteplase) work?
TNKase (tenecteplase) is known as a thrombolytic. It behaves just like a protein in your body called tissue plasminogen activator (tPA), which helps break up blood clots. This helps to restore bloodflow in your blood vessels.
How much TNKase (tenecteplase) will I receive, and how is it given?
TNKase (tenecteplase) is given as a quick injection into the vein (intravenous, IV) by a healthcare provider over a few seconds. The dose for a heart attack is 30 mg to 50 mg, depending on your body weight. While not FDA-approved for stroke, some clinical guidelines suggest TNKase (tenecteplase) as an alternative medication for treating ischemic stroke at a dose of 0.25 mg/kg of body weight. There are ongoing studies looking at the use of TNKase (tenecteplase) for stroke.
What are the side effects of TNKase (tenecteplase)?
Since TNKase (tenecteplase) stops the proteins that make blood clots from working, the most common side effect is bleeding. Hospitals typically have a specific protocol or program in place to thoroughly check for any risk factors and draw certain labs before giving you TNKase (tenecteplase). This makes sure the medication is as safe for you as possible.
How do I know if I'm allergic to TNKase (tenecteplase)?
Serious allergic reactions, including anaphylaxis (closing of the throat), have been reported after using TNKase (tenecteplase). If you experience rash, trouble breathing, or swelling of your lips, tongue, throat, or face, get medical help right away. Your provider will monitor you for several hours after you get TNKase (tenecteplase) to make sure you don't have a serious reaction.
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interactions

Interactions between TNKase (tenecteplase) and other drugs

TNKase (tenecteplase) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with TNKase (tenecteplase). Please note that only the generic name of each medication is listed below.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Defibrotide

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

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