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Tetrabenazine

Tetrabenazine Side Effects

Robert Chad Hakim, PharmD, BCCCPAllison Gourley, PharmD
Reviewed by Robert Chad Hakim, PharmD, BCCCP, Allison Gourley, PharmD
Last reviewed on February 3, 2022

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Sleepiness (31%)
  • Difficulty sleeping (22%)
  • Tiredness (22%)
  • Depression (19%)
  • Restlessness (19%)
  • Anxiety (15%)
  • Fall (15%)
  • Nausea (13%)
  • Upper respiratory tract infection (e.g., common cold, cough; 11%)
  • Easily irritated (9%)
  • Balance difficulty (9%)
  • Parkinsonism (e.g., slowed movement, shakiness; 9%)
  • Vomiting (6%)
  • Bruising (6%)

Less Common Side Effects

  • Dizziness
  • Headache
  • Slurred speech
  • Unsteady gait
  • Shortness of breath
  • Bronchitis
  • Low appetite
  • Obsessive reaction
  • Pain when urinating

Tetrabenazine serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Suicidal thoughts and behaviors: depressed mood, anxiety, panic attacks, difficulty sleeping, feeling angry or irritated, restlessness
  • Neuroleptic malignant syndrome: high fever, sweating, stiff muscles, confusion, not aware of your surroundings, fast or irregular heartbeat
  • Abnormal heart rhythm, including QT prolongation: chest pounding, short of breath, chest pain, feeling faint, lightheaded
  • Akathisia: restlessness, inability to sit still, squirmy or fidgety, agitated
When do Tetrabenazine possible side effects begin and end?
Time passed since treatment started:
H
D
W
M
Sleepiness
Restlessness
Parkinsonism
Risk of depression or suicidal thoughts
Seek immediate medical care if you experience this side effect.
If a line continues to the right, you'll likely keep experiencing this side effect once it starts.

Source: DailyMed

The following Tetrabenazine side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Body aches or pain

chills

cough

difficulty in breathing

difficulty with swallowing

discouragement

drowsiness

ear congestion

fear or nervousness

feeling sad or empty

fever

headache

inability to sit still

irritability

lack of appetite

loss of balance control

loss of interest or pleasure

loss of voice

mask-like face

nasal congestion

need to keep moving

relaxed and calm

restlessness

runny nose

shuffling walk

sleepiness or unusual drowsiness

sleeplessness

slow movement or reflexes

slurred speech

sneezing

sore throat

stiffness of arms and legs

tic-like (jerky) movements of the head, face, mouth, and neck

tiredness

trembling and shaking of fingers and hands

trouble concentrating

trouble sleeping

trouble with balance

unable to sleep

unusual tiredness or weakness

Less common

Burning while urinating

changes in patterns and rhythms of speech

cough producing mucus

difficult or painful urination

dizziness

shortness of breath

tightness in chest

trouble in speaking

trouble in walking

wheezing

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Blurred vision

diarrhea

dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly

fixed position of the eye

inability to move eyes

increased blinking or spasms of the eyelid

mood or mental changes

nausea and vomiting

seeing, hearing, or feeling things that are not there

shakiness in legs, arms, hands, or feet

sticking out of tongue

sweating

trembling or shaking of hands or feet

uncontrolled twisting movements of neck, trunk, arms, or legs

unusual facial expressions

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Bruising

large, flat, blue, or purplish patches in the skin

Less common

Decreased appetite

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Robert Chad Hakim, PharmD, BCCCP, started his full-time career as a clinical pharmacist at UCLA Health in the general medicine, general cardiology, and ICU units after completing residency in 2016. He also was the preceptor for the general medicine rotation from 2017 to 2021, which was a required rotation for all pharmacy residents.
Allison Gourley, PharmD, is a kidney and pancreas transplant pharmacist at a teaching hospital in the San Francisco Bay Area. When she’s not educating patients about their immunosuppressants, she's actively involved in transplant research.

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