Stalevo Side Effects
What should I watch for?
Visit your doctor or health care professional for regular checks on your progress. Do not take any additional medicines for Parkinson's disease without first consulting with your health care provider.
Entacapone may increase the side effects caused by Levodopa; Carbidopa such as nausea or restless movements. If you notice an increase in or the appearance of certain side effects that occurred only while you are taking Levodopa; Carbidopa, contact your physician. The dose of Levodopa-Carbidopa may need to be lowered. Do not decrease your medicine dose without asking your doctor or health care professional.
You may get dizzy or have difficulty controlling your movements. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol can increase possible dizziness. Avoid alcoholic drinks.
If you find that you have sudden feelings of wanting to sleep during normal activities, like cooking, watching television, or while driving or riding in a car, you should contact your health care professional.
Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe.
You may experience a 'wearing off' effect prior to the time for your next dose of this medicine. You may also experience an 'on-off' effect where the medicine apparently stops working for anything from a minute to several hours, then suddenly starts working again. Tell your doctor or health care professional if any of these symptoms happen to you. Your dosage may need adjustment.
A high protein diet can slow or prevent absorption of levodopa. Avoid high protein foods near the time of taking this medicine to help prevent this problem. You may want to eat higher protein foods later in the day or in small amounts. Discuss your diet with your doctor or nutritionist.
Do not take iron supplements within 2 hours of taking this medicine. The iron may decrease the amount of levodopa in your system and decrease the effectiveness of the drug
If you have diabetes, you may get a false-positive result for sugar in your urine. Check with your doctor or health care professional.
This medicine may discolor your urine, saliva or sweat, making it look darker or red in color. This is of no cause for concern. However, this may stain clothing or fabrics.
There have been reports of increased sexual urges or other strong urges such as gambling while taking some medicines for Parkinson's disease. If you experience any of these urges while taking this medicine, you should report it to your health care provider as soon as possible.
You should check your skin often for changes to moles and new growths while taking this medicine. Call your doctor if you notice any of these changes.
This medicine may cause a decrease in vitamin B6. You should make sure that you get enough vitamin B6 while you are taking this medicine. Discuss the foods you eat and the vitamins you take with your health care professional.
Common and Rare Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Twitching, twisting, or uncontrolled repetitive movements of the tongue, lips, face, arms, or legs
Incidence not known-Carbidopa and Levodopa and/or Levodopa alone
bloody or black, tarry stools
bloody or cloudy urine
change in size, shape, or color of an existing mole
changes in skin color
chest pain, discomfort, or tightness
difficult or labored breathing
difficulty with speaking
drooping eyelid (ptosis)
fast, irregular, or pounding heartbeat
fever with or without chills
general feeling of illness
hallucinations (seeing, hearing, or feeling things that are not there)
large, flat, blue, or purplish patches in the skin
large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
loss of appetite
loss of bladder control
lower abdominal or stomach pain
lower back or side pain
mole that leaks fluid or bleeds
muscle cramps or spasms
muscle pain or stiffness
muscle trembling, jerking, or stiffness
painful or difficult urination
pinpoint red spots on the skin
raised red swellings on the skin, the buttocks, legs, or ankles
severe mental changes
shakiness and unsteady walk
sores, ulcers, or white spots on the lips or in the mouth
trembling, or other problems with muscle control or coordination
unusual bleeding or bruising
unusual tiredness or weakness
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Acid or sour stomach
bitter, sour, or unusual taste in the mouth
burning feeling in the chest or stomach
excess air or gas in the stomach or intestines
lack or loss of strength
sleepiness or unusual drowsiness
stomach discomfort or upset
swollen mouth and tongue
tenderness in the stomach area
urge to have bowel movement
Incidence not known-Carbidopa and Levodopa and/or Levodopa alone
body aches or pain
burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
burning and upper abdominal or stomach pain
burning sensation of the tongue
clenching, gnashing, or grinding teeth
confusion about identity, place, and time
decreased mental acuity
excessive watering of the mouth
false or unusual sense of well-being
feeling like you will pass out
feeling of warmth
feeling sad or empty
hives or welts
increased interest in sexual ability, desire, drive, or performance
increased interest in sexual intercourse
lack of appetite
large, hard skin blisters
loss of voice
muscle spasm, especially of the neck and back
pain in the chest below the breastbone
painful or prolonged erection of the penis
pounding in the ears
problems with memory or speech
redness of the face, neck, arms, and occasionally upper chest
sense of stimulation
slow or fast heartbeat
trouble recognizing objects
trouble thinking and planning
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.