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Rejoyn

Used for Depression
Used for Depression

Rejoyn is the first and only smartphone app that's FDA cleared to reduce depression symptoms. It's used as an add-on treatment for people 22 years and older who are taking antidepressant medications. The app requires a prescription from a healthcare professional. Rejoyn provides lessons and brain-training exercises, and it's recommended to complete one task per day. The app works best when used regularly for 6 weeks.

Reviewed by:
reviewer
Kristianne Hannemann, PharmD
reviewer
Daisy Chau, PharmD
Last reviewed on September 13, 2024
BasicsPros & consPharmacist tipsFAQsWarningsDosageLatest newsReferencesPricesMedicare
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What is Rejoyn?

What is Rejoyn used for?

How Rejoyn works

Rejoyn is a smartphone application (app). It provides brain-training exercises that are thought to remodel your brain to help improve your mood. The treatment program is made of three parts:

Drug Facts

Common BrandsRejoyn
Drug ClassDigital therapeutic
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only

More on Rejoyn essentials

Rejoyn: man using mobile phone 2082812922

What to Know About the Rejoyn App for Depression

Written by Christina Aungst, PharmD
pros-and-cons

Pros and cons of Rejoyn

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Pros

Different scheduling options are available for your convenience

Doesn't interact with any medications

No known side effects related to the app

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Cons

Exercises can take 20-30 minutes to complete

Must use regularly for 6 weeks for best results

Not approved for people younger than 22 years old

pharmacist-tips

Pharmacist tips for Rejoyn

pharmacist

How to use Rejoyn:

  • After your prescriber sends a prescription for Rejoyn to a pharmacy that provides access codes for the app, download the Rejoyn app on your smartphone. You can find it in the Apple App Store and Google Play Store under "Rejoyn."

    • Read the Intructions for Use before using Rejoyn and ask your prescriber if you have any questions.

      • After you open Rejoyn for the first time, you'll need to create your account and enter your access code.

        • Follow the prompts on the Rejoyn app to start your treatment program that will continue over the next 6 weeks. There are a total of 18 therapeutic lessons and 18 brain exercises that you'll need to complete during this time.

          • You can take as long as you need to complete brain exercises on Rejoyn. But if you're interrupted for 15 minutes or more, you'll need to restart the exercise from the beginning.

            • If you miss a task on Rejoyn, you can catch up by completing two tasks the next day.

              • At the end of each week, exercises on Rejoyn will expire and you won't be able to take them. Lessons you weren't able to complete on Rejoyn will be unlocked and you can view them at any time while you have access to the app.

                • For best results, make sure to complete as many of the scheduled tasks per week on Rejoyn as possible. You can set a daily notification on your smartphone that reminds you to complete daily tasks.

                  • After 10 weeks, you won't be able to access Rejoyn anymore. Talk to your healthcare professional if you need more help treating your depression symptoms.

                    faqs

                    Frequently asked questions about Rejoyn

                    How well does Rejoyn work?
                    Compared to people using a different app, people using Rejoyn for 6 weeks had a greater improvement in their depression symptoms. In a clinical study, researchers used a depression rating scale to compare scores before and after treatment, where higher scores indicate more severe symptoms. After 6 weeks, People using Rejoyn had a larger drop in their scores compared to those using the other app. Follow up with your healthcare professional if you have more questions about how well Rejoyn might work for you.
                    How long does Rejoyn take to work?
                    In clinical studies, some people using Rejoyn noticed an improvement in their depression symptoms after 2 weeks. But, people regularly using the app continued to see improvements in their symptoms throughout the entire 6 weeks.
                    How can I get Rejoyn?
                    Rejoyn is only available with a prescription from a healthcare professional (HCP). Talk to your HCP about whether Rejoyn might be a good option for you, or you can get a prescription through a telehealth provider during a virtual consult. Your HCP will need to send your prescription to BlinkRx, an online pharmacy. They'll give you an access code that you can use to download Rejoyn from the Apple App Store or Google Play.
                    How much time will I need to spend using Rejoyn?
                    During the 6-week Rejoyn program, you'll need to complete 6 tasks per week in the app. You should plan on allowing 2 hours per week to finish the lessons and exercises.
                    How long do the effects of Rejoyn last?
                    Everyone responds differently to Rejoyn. In studies, people who used Rejoyn for 6 weeks and then stopped continued to see an improvement in their depression symptoms for up to 10 weeks. After the 6-week program ended, people were able to review the lessons they already completed for up to 4 weeks. More research is needed to understand how long the effects last after this time.
                    Can I use Rejoyn on my computer?
                    No. Rejoyn is currently only available for use on a smartphone by downloading the app. It can be used on both Apple (iOS) and Android systems. You won't be able to use Rejoyn on your computer or tablet at this time.
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                    What are the risks and warnings for Rejoyn?

                    Rejoyn can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                    risk-warning

                    Not to be used alone to treat depression

                    Rejoyn is meant to be used alongside an antidepressant medication. It hasn't been proven to be safe or effective to treat depression on its own. Continue taking your antidepressant(s) as prescribed by your healthcare professional while you're using Rejoyn.

                    risk-warning

                    Worsening depression

                    Rejoyn isn't able to notify your prescriber if your depression symptoms get worse. If you feel that your depression is getting worse or if you experience suicidal thoughts or behaviors, call 911 or get medical help right away.

                    dosage

                    Rejoyn dosage forms

                    Typical dosing for Rejoyn

                    Rejoyn provides cognitive behavioral therapy (CBT)-based lessons and emotional faces memory task (EFMT) exercises that alternate over a 6 week period. After this time, lessons are available for you to revisit for an additional 4 weeks.

                    It's recommended to complete one task per day, alternating between therapeutic lessons and brain exercises. But you can't do more than two tasks per day. Your healthcare professional will work with you to create a schedule for completing the lessons and exercises in the app.

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                    References

                    Best studies we found

                    Hoch, M. M., et al. (2019). Initial evidence for brain plasticity following a digital therapeutic intervention for depression. Chronic Stress.

                    Otsuka Precision Health, Inc. (2024). How to get Rejoyn.

                    Otsuka Precision Health, Inc. (2024). Rejoyn: Clinician brief summary.

                    View All References (1)

                    Otsuka Precision Health, Inc. (2024). Rejoyn: Patient instructions for use.

                    GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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