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Pyridostigmine

Pyridostigmine Side Effects

Aileen Chu, PharmD, BCPSRobert Chad Hakim, PharmD, BCCCP
Reviewed by Aileen Chu, PharmD, BCPS, Robert Chad Hakim, PharmD, BCCCP
Last reviewed on November 13, 2023

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

See Risks and Warnings.

Less Common Side Effects

These side effects are usually from taking too much pyridostigmine:

  • Nausea
  • Vomiting
  • Diarrhea
  • More bowel movements
  • Stomach cramps
  • More saliva
  • More phelgm in the airways
  • Small pupil size
  • Sweating
  • Muscle cramps
  • Muscle twitching
  • Muscle weakness

Pyridostigmine serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Myasthenic crisis: severe muscle weakness, trouble breathing

Source: DailyMed

The following Pyridostigmine side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Symptoms of overdose

Blurred vision

clumsiness or unsteadiness

confusion

convulsions (seizures)

diarrhea (severe)

increase in bronchial secretions or watering of mouth (excessive)

increasing muscle weakness (especially in the arms, neck, shoulders, and tongue)

muscle cramps or twitching

nausea or vomiting (severe)

shortness of breath, troubled breathing, wheezing, or tightness in chest

slow heartbeat

slurred speech

stomach cramps or pain (severe)

unusual irritability, nervousness, restlessness, or fear

unusual tiredness or weakness

Check with your doctor as soon as possible if any of the following side effects occur:

Rare

Redness, swelling, or pain at place of injection (for pyridostigmine injection only)

skin rash (does not apply to ambenonium)

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Diarrhea

increased sweating

increased watering of mouth

nausea or vomiting

stomach cramps or pain

Less common

Frequent urge to urinate

increase in bronchial secretions

unusually small pupils

unusual watering of eyes

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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