The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Diarrhea (9%)
- Headache (6%)
Less Common Side Effects
- Swelling
- Weight gain
- Upper respiratory tract infection
Pioglitazone/Metformin serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Heart failure: shortness of breath, tiredness, unusual swelling, sudden weight gain
- Lactic acidosis: fast breathing, shortness of breath, fast or slow heartbeat, heartbeat that doesn't feel normal, very upset stomach, vomiting, sleepiness, tiredness, feeling cold, muscle pain
- Bladder problems: pain while you urinate, constant need to urinate, blood in your urine
- Liver problems: nausea, vomiting, stomach pain, loss of appetite, unusual tiredness, dark urine, yellowing of your skin or the whites of your eyes
- Eye problem called macular edema: blurry vision, changes in vision
Source: DailyMed
The following Pioglitazone/Metformin side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
More common
Bladder pain
bloody or cloudy urine
difficult, burning, or painful urination
frequent urge to urinate
lower back or side pain
swelling of the face, fingers, feet, or lower legs
Less common
Pain or swelling in the arms or legs without any injury
pale skin
troubled breathing with exertion
unusual bleeding or bruising
unusual tiredness or weakness
Rare
blurred vision
chills
cold sweats
confusion
cool, pale skin
decreased appetite
dizziness
fast heartbeat
fast, shallow breathing
general feeling of discomfort
headache
increased hunger
loss of consciousness
muscle pain or cramping
nightmares
seizures
shakiness
sleepiness
slurred speech
stomach discomfort
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
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