Ogsiveo (nirogacestat) is the first and currently only oral tablet approved by the FDA to treat desmoid tumors in adults who require treatment by mouth or injection. It needs to be taken twice a day, with or without a meal. Common side effects include diarrhea, rash, and nausea. If you have diarrhea for more than 3 days or other side effects that won't go away, let your healthcare team know. They might need to lower your dose or stop the medication altogether.
Ogsiveo (nirogacestat) is a gamma secretase inhibitor, meaning it blocks an enzyme (protein) called gamma secretase. This action helps to slow down the growth of desmoid tumors.
| Common Brands | Ogsiveo |
|---|---|
| Drug Class | Gamma secretase inhibitor |
| Controlled Substance Classification | Not a controlled medication |
| Generic Status | No lower-cost generic available |
| Availability | Prescription only |
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Contact your healthcare provider immediately if you experience any of the following.
Ogsiveo (nirogacestat) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
In clinical studies, people who took Ogsiveo (nirogacestat) commonly experienced diarrhea. You might need to drink enough fluids to keep hydrated, since diarrhea can lead to dehydration. If you experience severe or watery diarrhea, fever, belly pain, loss of appetite, or nausea, let your care team know right away. Your care team might ask you to take antidiarrheal medications or lower your dose of Ogsiveo (nirogacestat).
Ogsiveo (nirogacestat) can affect your ability to have children. While it's not clear what the long-term effect is, it's possible that this medication can cause ovarian problems. If you plan to have children, talk with your care team about the benefits and risks of taking this medication. Tell your care team if you have any changes in your period or if you have symptoms such as hot flashes, night sweats, and vaginal dryness.
People who take Ogsiveo (nirogacestat) have reported higher liver enzymes (proteins), which may indicate liver problems. Make sure to get blood tests done while you take this medication so your care team can check your liver health. Let your healthcare provider know if you experience signs and symptoms of liver damage, such as upper right stomach pain, yellowing of the skin or whites of the eyes, or dark urine.
Rarely, people who take Ogsiveo (nirogacestat) might develop skin cancers. Your care team will do routine skin exams before and during treatment to make sure you aren't at risk for skin cancer. Let your primary care provider know if you notice any new skin growth or changes to your skin.
Ogsiveo (nirogacestat) can cause low levels of certain electrolytes, such as potassium and phosphate. Your care team will monitor your electrolyte levels regularly during treatment to make sure this medication is safe for you. In some cases, you might be asked to take a potassium or phosphate supplement. Let your care team know if you experience fast heart rate, muscle weakness, muscle pain, or confusion.
Taking Ogsiveo (nirogacestat) during pregnancy might raise the risk for death in unborn babies and loss of pregnancy. Because of this potential risk, if you're able to have a child, your primary care provider will ask you to take a pregnancy test. They'll also discuss birth control options during your treatment with this medication. Make sure to use an effective form of contraception while taking Ogsiveo (nirogacestat) and for one week after. If you're pregnant or are planning to become pregnant, discuss your treatment options with your care team.
Tablet| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 50mg | 60 tablets | $10,028.65 | $167.14 |
The typical dose is 150 mg by mouth twice daily.
Your dose might differ if you have diarrhea for 3 days and longer, liver problems, or changes in certain electrolytes.
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No. Chemotherapy works by attacking all cells that are growing quickly, such as cancer cells. But Ogsiveo works in a different way. Instead of attacking cells that grow quickly, Ogsiveo is a targeted therapy that blocks a specific protein called gamma secretase from working.
Ogsiveo hasn’t been studied in pregnant people, but animal studies showed that this medication caused serious harm to baby animals and mothers. If you're able to become pregnant, your primary care provider will ask you to take a pregnancy test before taking Ogsiveo. Make sure to use birth control, like condoms, during treatment and for one week after. If you’re pregnant or planning on becoming pregnant, talk to your care team to discuss the risks of taking this medication.
It's not clear whether Ogsiveo can get into breastmilk. If you're taking Ogsiveo, avoid breastfeeding during treatment and for one week after. Some alternatives you can give your baby in the meantime include previously stored breast milk or formula. If you have any questions, talk with your care team.
Diarrhea is a very common side effect of Ogsiveo. To help with diarrhea, you might be able to take loperamide (Imodium A-D) over-the-counter. Talk with your care team if your diarrhea doesn't get better after 3 days. Your primary care provider can adjust your dose of Ogsiveo or recommend other medications to help with your symptoms.
Ogsiveo hasn’t been studied in human fertility, but animal studies showed that this medication lowered the ability to have babies in both male and female rats. In addition, Ogsiveo has been shown to cause ovarian problems, such as hot flashes and irregular periods. If you plan to have children, talk with your primary care provider about the benefits and risks of taking this medication.
Yes. Certain heartburn medications, such as omeprazole (Prilosec) and famotidine (Pepcid AC), can cause Ogsiveo to work less well. Consider taking antacids like Tums (calcium carbonate) for heartburn instead. Make sure to take Ogsiveo 2 hours before or 2 hours after taking antacids to avoid an interaction.
