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Kynamro

mipomersen
Used for High Cholesterol
Used for High Cholesterol

Kynamro (mipomersen) is an injectable medication that helps lower cholesterol levels in people with a condition called homozygous familial hypercholesterolemia (HoFH). It's used together with other cholesterol-lowering medications and diet. This medication is no longer available in the United States.

Reviewed by:
reviewer
Yen Nguyen, PharmD
reviewer
Cydnee Ng, PharmD
Last reviewed on November 29, 2021
BasicsFAQsInteractionsPricesMedicare
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What is Kynamro (mipomersen)?

How Kynamro (mipomersen) works

Drug Facts

Common BrandsKynamro (brand no longer available)
Drug ClassAntilipemic
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityDiscontinued
faqs

Frequently asked questions about Kynamro (mipomersen)

What is homozygous familial hypercholesterolemia (HoFH)?
Homozygous familial hypercholesterolemia (HoFH) is a type of rare genetic condition that causes lifelong high cholesterol. This condition raises "bad" cholesterol, like low-density lipoprotein cholesterol (LDL-C), in your blood. Too much "bad" cholesterol can cause atherosclerosis, where cholesterol builds up in your arteries (blood vessels) and blocks blood from flowing to important parts of your body. This can cause heart attacks, strokes, and other heart or blood circulation problems. So if HoFH is left untreated, this condition can lead to atherosclerosis earlier in life than usual and a higher risk of heart attack and stroke.
What is Kynamro (mipomersen)?
Kynamro (mipomersen) is a medication injected under the skin (subcutaneously) once a week to help lower a variety of "bad" cholesterol levels in your blood. These levels include low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (apo B), total cholesterol (TC), and non-high-density lipoprotein cholesterol (non-HDL-C). Kynamro (mipomersen) is given along with other cholesterol-lowering medications and proper diet to help lower "bad" cholesterol levels to lower your risk of atherosclerosis, heart attack, and stroke.
Is Kynamro (mipomersen) still available?
No, Kynamro (mipomersen) is no longer available in the United States.
Why was Kynamro (mipomersen) discontinued?
It's unclear why Kynamro (mipomersen) was taken off the market, but the FDA withdrew its approval for this medication as of August 2019.
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interactions

Interactions between Kynamro (mipomersen) and other drugs

Kynamro (mipomersen) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Kynamro (mipomersen). Please note that only the generic name of each medication is listed below.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

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