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Insulin Lispro Coupon - Insulin Lispro 10ml of 100 units/ml vial

insulin lispro

Generic Humalog
Used for Diabetes Type 2, Diabetes Type 1
Used for Diabetes Type 2, Diabetes Type 1

Humalog (insulin lispro) is a fast-acting insulin for adults and children with diabetes. It helps prevent and treat high blood sugar from meals. This medication lowers your blood sugar levels by moving the sugar from your blood and into your body. Humalog (insulin lispro) is typically given as an injection under the skin. In certain situations, it's injected into the veins by a healthcare provider. Humalog (insulin lispro) is available as vials and ready-to-use prefilled pens. Side effects include headache and low blood sugar (hypoglycemia).

Reviewed by:
reviewer
Robert Chad Hakim, PharmD, BCCCP
reviewer
Cydnee Ng, PharmD
Last reviewed on October 26, 2023
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageInteractionsCostContraindicationsAlternativesLatest newsImagesReferencesPricesMedicare
basics-icon

What is Humalog (insulin lispro)?

What is Humalog (insulin lispro) used for?

How Humalog (insulin lispro) works

Humalog (insulin lispro) is an insulin, which is a natural hormone your body normally makes to lower glucose (sugar) levels in the blood. It helps your body absorb sugar from your bloodstream after you eat a meal and store it for energy. Insulins also stop your liver from making glucose.

Are you looking for information on Admelog (insulin lispro) or Humalog Mix 75/25 (insulin lispro protamine / insulin lispro) instead?

Drug Facts

Common BrandsHumalog, Humalog Kwikpen, Humalog Junior Kwikpen, Humalog Tempo Pen
Drug ClassInsulin
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only

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What are the side effects of Humalog (insulin lispro)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Type 1 diabetes:
  • Flu-like symptoms (35%)
  • Sore throat (33%)
  • Runny nose (25%)
  • Headache (30%)
  • Pain (20%)
  • Cough (17%)
  • Infection (14%)
Type 2 diabetes:
  • Headache (12%)
  • Pain (11%)
  • Infection (10%)

Other Side Effects

  • Weight gain
  • Swelling
  • Reactions at the injection site (e.g., redness, swelling, itching)

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Severely low blood sugar: dizziness, shakiness, feeling confused, feeling irritable or anxious, feeling faint, sweating, extreme hunger, not able to think clearly
  • Ketoacidosis (high ketone levels in the blood): nausea, vomiting, stomach pain, tiredness, thirsty, dry mouth, fruity breath, trouble breathing
  • Severely low potassium levels: weakness, muscle cramps or twitches, constipation, abnormal heartbeat, tiredness, trouble breathing
  • Severe allergic reactions: rash; hives; swelling of face, tongue, and throat; trouble breathing

Source: DailyMed

More on Humalog (insulin lispro) side effects

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The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Anxious or nervous feeling

behavior change similar to being drunk

blurred vision

chills

cold sweats

confusion or difficulty thinking

depression

dizziness or lightheadedness

drowsiness

excessive hunger

fast heartbeat

fever

headache

irritability or abnormal behavior

lower back or side pain

nightmares

painful or difficult urination

restless sleep

seizures

shakiness

slurred speech

tingling in the hands, feet, lips, or tongue

Less common

Dry, red, hot, or irritated skin

Rare

Depression of the skin at the injection site

dryness of the mouth

fast or weak pulse

itching, redness, or swelling at the injection site

muscle cramps or pain

nausea

skin rash or itching over the whole body

sweating

thickening of the skin at the injection site

trouble breathing

unusual tiredness or weakness

vomiting

Incidence not known

Bloating or swelling of the face, arms, hands, lower legs, or feet

decreased urine

difficulty with swallowing

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

fast, pounding, or irregular heartbeat or pulse

hives or itching skin

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

redistribution or accumulation of body fat

tightness in the chest

unusual weight gain or loss

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Body aches or pain

congestion

runny nose

sneezing

sore throat

stuffy nose

tender, swollen glands in the neck

unusual tiredness or weakness

voice changes

Incidence not known

Redness, swelling, or itching at the injection site

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Humalog (insulin lispro)

thumbs-up

Pros

Starts to work within 15 minutes to lower blood sugar levels

Dose can be easily adjusted to make a treatment plan that's tailored to your specific needs

Available as a prefilled pen for easier and convenient use

Can use at home after proper training

Can use in children as young as 3 years old with Type 1 diabetes

thumbs-down

Cons

Given multiple times a day (before each meal)

Must give as an injection

Might be hard for some people to take properly

Risk of low blood sugar

Can cause weight gain

pharmacist-tips

Pharmacist tips for Humalog (insulin lispro)

pharmacist

  • You should get training from your provider or pharmacist on how to use Humalog (insulin lispro) properly and safely. This is important to avoid accidentally hurting yourself or wasting the medication. Read the instructions on how to use the U-100 vial, KwikPen U-100, KwikPen U-200, or Junior KwikPen U-100. Contact your provider or pharmacist if you have any questions.

    • Don't mix Humalog (insulin lispro) with other insulins (except NPH insulin) within the same syringe. Check with your provider or pharmacist about mixing Humalog (insulin lispro) with NPH insulin.

      • Don't use Humalog (insulin lispro) if you plan to skip a meal, unless your provider specifically told you to do so. Using Humalog (insulin lispro) without a meal raises your risk for hypoglycemia (dangerously low blood sugar).

        • Ask your provider when you should check your blood sugar during the day as you use Humalog (insulin lispro). Keep a log of your blood sugar readings and share it with your provider at your office visits. This helps you and your provider keep track of how well you're responding to the medication and whether you need dose adjustments.

          • Make sure you and your family members know how to recognize and treat low blood sugar, like shakiness, anxiety, and hunger. Keep fast-acting sugar, such as glucose tablets, with you at all times so you can take it if your blood sugar level drops too low. Follow the "15-15 rule" to treat low blood sugar levels (below 70 mg/dL).

            Tips on how to store Humalog (insulin lispro):

            • Store unopened vials and pens in the refrigerator until the expiration date. You can also keep them at room temperature for up to 28 days.

              • Store opened vials in the refrigerator or at room temperature for up to 28 days. Keep opened pens at room temperature for up to 28 days; don't put them in the refrigerator.

                Tips for the Humalog (insulin lispro) pens:

                • Be sure you know your dose and double check the concentration (strength) of your Humalog (insulin lispro) pens before using the medication. There are two strengths: U-100 (contains 100 units/mL) and U-200 (contains 200 units/mL). Call your provider right away if you think you have pens with the wrong strength.

                  • Prime the Humalog (insulin lispro) pen each time before you inject the medication. This prepares the pen for your dose by getting rid of air bubbles to make sure your dose is accurate. Follow your pen's instructions to prime it properly.

                    Tips on how to use Humalog (insulin lispro):

                    • For under-the-skin injections: Inject Humalog (insulin lispro) within 15 minutes before a meal or right after a meal. Inject the medication under the skin in the stomach area, buttocks, upper legs (thighs), or upper arms. Choose a different injection site each time to prevent hard lumps from forming in your skin.

                      • For continuous infusion pumps: Be sure to infuse into an area of the body recommended by the manufacturer of the pump. Rotate injection sites to prevent skin irritation. Change the medication in the pump at least once per week or according to the user manual, whichever is shorter. Also replace any Humalog (insulin lispro) in the pump that's been exposed to temperatures above 98.6°F.

                        • Always use a new needle for each injection to help prevent infections and blocked needles. Don't reuse or share your injection supplies with other people to avoid spreading infections.

                          • After injecting the medication, throw the needle or syringe away in a sharps container or something made of heavy-duty plastic (e.g., empty milk carton, laundry detergent bottle). This helps lower the risk of needle-stick injuries. Don't throw away needles or syringes in your trash can. Visit the FDA's website for guidance on how to throw away your sharps container safely in your specific state.

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                            faqs

                            Frequently asked questions about Humalog (insulin lispro)

                            Is Humalog (insulin lispro) a fast-acting insulin?
                            Yes, Humalog (insulin lispro) is a fast-acting (or rapid-acting) insulin. It starts to work within 15 minutes after it's injected. Because it works so quickly, make sure to inject Humalog (insulin lispro) within only 15 minutes before a meal so that it works well to keep the food from making your blood sugar too high.
                            How long does Humalog (insulin lispro) last?
                            The blood sugar-lowering effects of Humalog (insulin lispro) last for about 2 to 4 hours after a dose. This is why Humalog (insulin lispro) is typically given multiple times per day (that is, with each meal).
                            Are Humalog (insulin lispro) and Novolog the same?
                            No. Humalog (insulin lispro) and NovoLog (insulin aspart) are both rapid-acting insulins that share a lot of similarities, but they're two completely different medications. One of the main differences is that Humalog (insulin lispro) can be used in children at least 3 years old with Type 1 diabetes, whereas Novolog (insulin aspart) can be used in children at least 2 years old with Type 1 diabetes. Another main difference is that you typically inject Humalog (insulin lispro) within 15 minutes of a meal, whereas Novolog (insulin aspart) is injected within 5 to 10 minutes before a meal.
                            Is Humalog (insulin lispro) regular insulin?
                            No, Humalog (insulin lispro) and Humulin R (insulin regular) are two completely different types of insulins. Both can be used at mealtimes to manage your blood sugar after eating. The main difference is how fast they start to work and how long they last. Humalog (insulin lispro) is a rapid-acting insulin that starts to work within 15 minutes and lasts 2 to 4 hours. On the other hand, Humulin R (insulin regular) is a short-acting insulin that starts to work within 30 minutes and lasts 3 to 6 hours. This means that you can inject Humulin R (insulin regular) a little bit longer before meals than Humalog (insulin lispro), and it lasts longer than Humalog (insulin lispro).
                            Does Humalog (insulin lispro) need to be refrigerated?
                            It depends on whether you've opened Humalog (insulin lispro) or not. It's preferred that you store unopened vials and pens in the refrigerator because you'll be able to use them until their expiration dates. You can keep them at room temperature too, but only for up to 28 days before you need to throw them out. You can keep opened vials either in the refrigerator or at room temperature. And opened pens should only be stored at room temperature; don't put the pens back in the refrigerator after opening. Ask your provider or pharmacist if you're not sure whether you need to store Humalog (insulin lispro) in the refrigerator or whether you can keep it at room temperature.
                            How long is Humalog (insulin lispro) good for after opening?
                            In general, Humalog (insulin lispro) is good for 28 days after opening. Make sure to write down the expiration date, which is 28 days after you open the medication. Don't use Humalog (insulin lispro) past this date, even if there's still some medication left. This time frame might be different in certain situations, such as when Humalog (insulin lispro) needs to be diluted. Ask your provider or pharmacist if you're not sure how long Humalog (insulin lispro) is good for after opening.
                            How much Humalog (insulin lispro) can you take in a day?
                            There isn't a maximum amount of Humalog (insulin lispro) you can take in a day. Everyone's insulin requirements will be different; some people need very low doses, while others might need very high doses. Your provider will work with you to find a dosing plan that works best for you. It typically depends on many things, like whether you have Type 1 or Type 2 diabetes, your blood sugar levels, and how they respond to insulin. The most important and safest thing to do is to always follow your provider's instructions on how much Humalog (insulin lispro) to use. If you feel that your dose isn't enough based on your blood sugar readings, don't use extra doses of Humalog (insulin lispro) because this can raise your risk for low blood sugar (hypoglycemia). Instead, call your provider to discuss your blood sugar results and ask whether you need any dose adjustments.
                            How long after taking Humalog (insulin lispro) can you take Lantus?
                            You can take Humalog (insulin lispro) and Lantus (insulin glargine) at the exact same time if that's how your provider prescribed it to you. Both medications help control your blood sugar but for different reasons. Lantus (insulin glargine) is a long-acting insulin that helps control your blood sugar all day long. Humalog (insulin lispro) can be given along with Lantus (insulin glargine) to help balance your blood sugar levels after your meal. Talk with your provider to come up with a dosing schedule that works best for you if you're taking both Humalog (insulin lispro) and Lantus (insulin glargine).
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                            What are the risks and warnings for Humalog (insulin lispro)?

                            Humalog (insulin lispro) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                            risk-warning

                            Spread of infections from sharing injection supplies

                            Never share Humalog (insulin lispro) pens, syringes, needles, or cartridges with anyone else. Sharing Humalog (insulin lispro) and injection supplies with someone can raise the risk of spreading very dangerous infections to other people (including yourself).

                            risk-warning

                            Low blood sugar (hypoglycemia)

                            • Risk factors: Changes in diet and exercise | Switching to Humalog (insulin lispro) from a different type of insulin | Drinking alcohol | Taking other medications for diabetes together with Humalog (insulin lispro) | Liver or kidney problems

                              Using Humalog (insulin lispro) alone or together with other blood sugar medications can cause your blood sugar levels to drop too low, which can be life-threatening. Always check the medication labels of all your diabetes medications to make sure you're taking the right one, especially if you're injecting more than one type of insulin.

                              Make sure you and your loved ones know how to recognize symptoms of low blood sugar, such as feeling shaky; being nervous, anxious, or confused; or feeling very hungry. Check your blood sugar if you have any of these symptoms.

                              It's important to know how to treat low blood sugar. Carry some form of fast-acting sugar (e.g., glucose tablets, hard candy, fruit juice) with you at all times while you're taking this medication. You can use these to raise your blood sugar quickly if it becomes too low.

                              risk-warning

                              Low blood potassium levels

                              • Risk factors: Taking other medications that lower potassium levels

                                Humalog (insulin lispro) can lower the levels of potassium in your blood, which can sometimes be dangerous. You're at risk if you're already taking medications that lower your potassium, like certain diuretics (water pills). Your provider will check your potassium levels regularly and might give you medications to keep your potassium in the normal range. Tell your provider if you have symptoms of low potassium, such as weakness, muscle cramps or twitches, nausea, vomiting, or abnormal heartbeats.

                                risk-warning

                                Swelling from fluid buildup and risk of heart failure when taken with certain blood sugar medications

                                • Risk factors: Taking glitazones together with Humalog (insulin lispro) | History of heart failure

                                  Taking Humalog (insulin lispro) with medications called glitazones (also known as thiazolidinediones), like pioglitazone (Actos), can cause your body to hold onto fluid. This can worsen or lead to heart failure. Let your provider know if you've noticed sudden weight gain or if you have symptoms of heart failure, such as trouble breathing, tiredness, or headache. Your provider might need to make changes to your blood sugar medications.

                                  risk-warning

                                  Dangerously high blood sugar levels or buildup of ketones (for people who use insulin pump)

                                  • Risk factors: Insulin pump not working properly

                                    If you're using an insulin pump to inject Humalog (insulin lispro), check that your pump is working properly and that you know how to use it correctly. When the pump isn't work properly, you're at risk of having extremely high blood sugar levels or a serious complication of diabetes called ketoacidosis. Call your provider right away if you can't fix your pump quickly. Your provider might recommend that you inject Humalog (insulin lispro) in other ways in the meantime. Tell your provider as soon as possible if you have symptoms of ketoacidosis, such as tiredness, fruity-smelling breath, or vomiting.

                                    dosage

                                    Humalog (insulin lispro) dosage forms

                                    The average cost for 1 vial of 10ml of 100 units/ml of Humalog (insulin lispro) is $74.44 with a free GoodRx coupon. This is 63.86% off the average retail price of $205.99.
                                    carton
                                    Carton
                                    DosageQuantityPrice as low asPrice per unit
                                    five 3ml cartridges of 100 units/ml1 carton$161.88$161.88
                                    five 3ml junior kwikpens of 100 units/ml1 carton$167.90$167.90
                                    five 3ml kwikpens of 100 units/ml1 carton$165.49$165.49
                                    two 3ml kwikpens of 200 units/ml1 carton$244.75$244.75
                                    cartridge
                                    Cartridge
                                    DosageQuantityPrice as low asPrice per unit
                                    3ml of 100 units/ml2 cartridges$71.25$35.62
                                    kwikpen
                                    Kwikpen
                                    DosageQuantityPrice as low asPrice per unit
                                    3ml of 100 units/ml5 kwikpens$167.87$33.57
                                    3ml of 200 units/ml14 kwikpens$594.02$42.43
                                    vial
                                    Vial
                                    DosageQuantityPrice as low asPrice per unit
                                    3ml of 100 units/ml10 vials$209.86$20.99
                                    10ml of 100 units/ml1 vial$74.44$74.44

                                    Typical dosing for Humalog (insulin lispro)

                                    Your healthcare provider will work with you to find the dose that works best for you. Your dose depends on many things, such as whether you have Type 1 or Type 2 diabetes, your blood sugar levels and how they change with insulin, and how you're injecting the medication (under the skin, into the vein, using an insulin pump).

                                    • For injections under the skin: Inject Humalog (insulin lispro) under the skin in the stomach, thigh, upper arm, or buttocks area within 15 minutes before a meal or right after a meal.

                                    • For injections through the vein: Insulin lispro 100 units/mL (Humalog U-100) can be given as an injection into the vein by a healthcare provider. The dose depends on the type of diabetes you have and your weight.

                                    • For continuous insulin pumps: Use the insulin pump according to your provider's instructions. Follow the directions from your insulin pump manufacturer to set up and use the pump.

                                    interactions

                                    Interactions between Humalog (insulin lispro) and other drugs

                                    Humalog (insulin lispro) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Humalog (insulin lispro). Please note that only the generic name of each medication is listed below.

                                    More on Humalog (insulin lispro) interactions

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                                    Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                                    Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                                    drug-cost

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                                    contraindications-icon

                                    Humalog (insulin lispro) contraindications

                                    Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Humalog (insulin lispro) will not be safe for you to take.

                                    • When you have low blood sugar (hypoglycemia)

                                    alternatives

                                    What are alternatives to Humalog (insulin lispro)?

                                    There are a number of medications that your doctor can prescribe in place of Humalog (insulin lispro). Compare a few possible alternatives below.
                                    Humalog (insulin lispro)
                                    Used for:
                                    $66.13 Lowest GoodRx priceView Prices
                                    Admelog (insulin lispro)
                                    Used for:
                                    $108.85 Lowest GoodRx priceView Prices
                                    NovoLog (insulin aspart)
                                    Used for:
                                    $80.60 Lowest GoodRx priceView Prices
                                    latest news

                                    What is the latest news about Humalog (insulin lispro)?

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                                    images

                                    Humalog (insulin lispro) images

                                    colorless - Insulin Lispro 100unit / mL Solution for Injection
                                    This medicine is Colorless Vial.colorless - Insulin Lispro 100unit / mL Solution for Injection

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                                    References

                                    Best studies we found

                                    American Diabetes Association. (n.d.). Hypoglycemia (low blood glucose).

                                    American Diabetes Association. (n.d.). Insulin basics.

                                    Eli Lilly and Company. (2023). Humalog- insulin lispro injection, solution; Humalog Kwikpen - insulin lispro injection, solution; Humalog Junior Kwikpen - insulin lispro injection, solution; Humalo Tempo pen - insulin lispro injection, solution [package insert]. DailyMed.

                                    View All References (6)

                                    Eli Lilly and Company. (2023). Instructions for use: Humalog® (HU-ma-log) (insulin lispro) injection, for subcutaneous use- 3 mL or 10 mL multiple-dose vial (100 units per mL, U-100).

                                    Eli Lilly and Company. (2023). Instructions for use: Humalog® (HU-ma-log) Junior KwikPen® (insulin lispro) injection, for subcutaneous use- 3 mL single-patient-use-pen (100 units per mL).

                                    Eli Lilly and Company. (2023). Instructions for use: Humalog® (HU-ma-log) KwikPen® (insulin lispro) injection, for subcutaneous use- 3 mL single-patient-use-pen (100 units per mL).

                                    Eli Lilly and Company. (2023). Instructions for use: Humalog® (HU-ma-log) KwikPen® (insulin lispro) injection, for subcutaneous use- 3 mL single-patient-use-pen (200 units per mL).

                                    U.S. Food and Drug Administration. (2021). Safely using sharps (needles and syringes) at home, at work and on travel.

                                    You and Your Hormones. (2021). Insulin.

                                    GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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