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Glyburide/Metformin

Glyburide/Metformin Side Effects

Ally Tsai, PharmDKristianne Hannemann, PharmD
Reviewed by Ally Tsai, PharmD, Kristianne Hannemann, PharmD
Last reviewed on December 17, 2024

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Low blood sugar levels (up to 38%)
  • Diarrhea (17%)
  • Headache (9%)
  • Nausea or vomiting (8%)
  • Belly pain (7%)
  • Dizziness (6%)

Less Common Side Effects

  • Redness or itching on the skin
  • Rash

Glyburide/Metformin serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Severe skin or allergic reactions: rash, blisters, sores, trouble breathing, swelling
  • Low blood sugar: shakiness, fast heartbeat, sweating, dizziness, anxiety, confusion, feeling very hungry
  • Buildup of lactic acid: confusion, feeling weak, fast heartbeat, rapid breathing, no appetite, nausea, vomiting

Source: DailyMed

The following Glyburide/Metformin side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Anxious feeling

behavior change similar to being drunk

blurred vision

cold sweats

confusion

convulsions (seizures)

cool, pale skin

cough

difficulty with concentrating

drowsiness

excessive hunger

fast heartbeat

fever

headache (continuing)

nausea

nervousness

nightmares

restless sleep

shakiness

slurred speech

sneezing

sore throat

unconsciousness

unusual tiredness or weakness

Rare

Abdominal or stomach discomfort

decreased appetite

diarrhea

fast shallow breathing

general feeling of discomfort

muscle pain or cramping

unusual sleepiness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Dizziness

headache

vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Ally Tsai, PharmD
Reviewed by:
Ally Tsai, PharmD
Ally Tsai, PharmD, is a medication therapy management (MTM) pharmacist with 6 years of experience. As an MTM pharmacist, she helps people with complex medication regimens get the best results by conducting comprehensive medication reviews.
Kristianne Hannemann, PharmD, is a licensed pharmacist in California. She has been a retail pharmacy manager and staff pharmacist for over 7 years and has contributed drug information content to different health companies.

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