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Epinephrine (Adrenalin)

Epinephrine (Adrenalin) Side Effects

Robert Chad Hakim, PharmD, BCCCPConnie Zheng, PharmD
Reviewed by Robert Chad Hakim, PharmD, BCCCP, Connie Zheng, PharmD
Last reviewed on August 8, 2023

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Anxiety
  • Restlessness
  • Tremor
  • Weakness
  • Dizziness
  • Sweating
  • Pounding heart
  • Nausea/vomiting
  • Headache
  • Looking pale

Please note: The side effects listed were reported in cases where people received [[EDITOR|DRUG_DISPLAY_NAME]] injections into the muscle or under the skin.

Less Common Side Effects

  • High heart rate
  • Irregular heart rhythm
  • High blood pressure
  • Chest pain
  • Kidney problems
  • Breathing problems

Epinephrine (Adrenalin) serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • High blood pressure: headache, chest pain, dizziness, blurry vision
  • Irregular heart rhythm (arrhythmias): fatigue, weakness, dizziness, shortness of breath, chest pain, sweating
  • Skin problems: pain, warmth, swelling, tenderness, redness at injection site
  • Too much fluid in the lungs: shortness of breath, wheezing, quick, shallow breaths
  • Kidney problems: low urine output, muscle cramps, swelling in arms/legs
  • Serious allergic reaction: hives, rash, blisters, skin reddening, swelling of the lips or tongue, difficulty breathing
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Source: DailyMed

The following Epinephrine (Adrenalin) side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

Abnormal or decreased touch sensation

anxiety

arm, back, or jaw pain

bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

blurred vision

chest pain, tightness, heaviness, or discomfort

cold, pale, or bluish color of the skin of the fingers or toes

confusion

difficulty in speaking

dizziness

double vision

fainting

fast, slow, irregular, pounding, or racing heartbeat or pulse

headache

inability to move the arms, legs, or facial muscles

inability to speak

nausea

numbness, tingling, or pain in the fingers

paleness of the skin

pounding in the ears

restlessness

shakiness in the legs, arms, hands, or feet

slow speech

sweating

trembling or shaking of the hands or feet

trouble breathing

unusual tiredness or weakness

vomiting

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Agitation

coldness of the skin

confusion

decreased awareness or responsiveness

decreased urine output

depression

drowsiness

hostility

irritability

lightheadedness

loss of consciousness

muscle twitching

rapid weight gain

rapid, deep breathing

seizures

severe sleepiness

stomach cramps

swelling of the face, ankles, or hands

unusual drowsiness, dullness, or feeling of sluggishness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Robert Chad Hakim, PharmD, BCCCP, started his full-time career as a clinical pharmacist at UCLA Health in the general medicine, general cardiology, and ICU units after completing residency in 2016. He also was the preceptor for the general medicine rotation from 2017 to 2021, which was a required rotation for all pharmacy residents.
Connie Zheng, PharmD, is a drug information pharmacist at GoodRx and a licensed pharmacist in California. She has over 6 years of experience working in independent pharmacies.

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