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Edarbyclor Coupon - Edarbyclor 40mg/25mg tablet

Edarbyclor

azilsartan / chlorthalidone
Used for Hypertension
Used for Hypertension

Edarbyclor (azilsartan / chlorthalidone) is used to treat high blood pressure in adults. It's a combination medication that contains an angiotensin II receptor blocker (ARB), azilsartan, and a thiazide diuretic, chlorthalidone, both of which are first-choice blood pressure medications. Edarbyclor might be a good option for people who need many medications to manage blood pressure. The tablets are taken by mouth once per day. This medication has few side effects, which can include dizziness. It's brand name only, though; there's no lower-cost generic yet.

Reviewed by:
reviewer
Robert Chad Hakim, PharmD, BCCCP
reviewer
Kristianne Hannemann, PharmD
Last reviewed on August 26, 2024
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageInteractionsCostContraindicationsAlternativesLatest newsImagesReferencesPricesMedicare
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What is Edarbyclor (azilsartan / chlorthalidone)?

What is Edarbyclor (azilsartan / chlorthalidone) used for?

How Edarbyclor (azilsartan / chlorthalidone) works

Edarbyclor (azilsartan / chlorthalidone) is a combination of two blood pressure medications.

  • Azilsartan is an angiotensin II receptor blocker (ARB). It works by blocking angiotensin II, a hormone that's naturally found in the body. This helps relax your blood vessels so blood can flow through more easily.

  • Chlorthalidone is a thiazide diuretic (water pill). It works in your kidneys to remove extra water and certain electrolytes (like sodium and potassium). This lessen the amount of fluid that flows through your blood vessels, which helps lower blood pressure.

Are you looking for information on Edarbi (azilsartan) or chlorthalidone (Thalitone) instead?

Drug Facts

Common BrandsEdarbyclor
Drug ClassARB / Diuretic (water pill)
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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What are the side effects of Edarbyclor (azilsartan / chlorthalidone)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Dizziness (9%)
  • Fatigue (2%)

Other Side Effects

  • Low blood pressure
  • Feeling faint

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Severe allergic reaction: trouble breathing; rash; swelling of the face, arms or legs, lips, tongue, or throat
  • Dangerously low blood pressure: dizziness, lightheadedness, pale skin, feeling faint
  • Serious kidney problems: urinating less often than usual; swelling in your feet, ankles, or hands; unexplained weight gain

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

Blurred vision

confusion

convulsions

decreased urine

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

dry mouth

fainting

increased thirst

irregular heartbeat

loss of appetite

muscle pain or cramps

nausea or vomiting

numbness or tingling in the hands, feet, or lips

shortness of breath

sweating

unusual tiredness or weakness

Incidence not known

Ankle, knee, or great toe joint pain

joint stiffness or swelling

lower back, side, or stomach pain

swelling of the feet or lower legs

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Dizziness

Rare

Cough

diarrhea

lack or loss of strength

muscle spasm

Incidence not known

Headache

loss of appetite

rash

stomach cramps

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Edarbyclor (azilsartan / chlorthalidone)

thumbs-up

Pros

Has two first-choice blood pressure medications within a single pill

Taken by mouth once per day

Can take together with other blood pressure medications, if needed

thumbs-down

Cons

Available as a brand-name medication only

Might make you urinate more often

Not safe to take while pregnant or breastfeeding

Can't change the dose of each medication in Edarbyclor

pharmacist-tips

Pharmacist tips for Edarbyclor (azilsartan / chlorthalidone)

pharmacist

  • Take Edarbyclor (azilsartan / chlorthalidone) with or without food at any time of day.

    • It's recommended that you check your blood pressure at home, keep a record of your readings, and share this log with your prescriber at each follow-up visit. This helps your prescriber understand how well Edarbyclor (azilsartan / chlorthalidone) is working for you and they can recommend any dose changes if needed.

      • Mark your calendar with your appointments to see your prescriber and to get any blood work done as you take Edarbyclor (azilsartan / chlorthalidone). Your care team will order tests during treatment to check your electrolyte levels and kidney function. These lab results help make sure the medication is safe for you to take.

        • Take Edarbyclor (azilsartan / chlorthalidone) exactly as prescribed. Don't lower your dose or stop taking the medication suddenly without talking to your prescriber first. Otherwise, your blood pressure might rise quickly. Your prescriber might lower your dose slowly over time before you can completely stop taking. This prevents your blood pressure from changing too quickly while you're making these adjustments.

          • Edarbyclor (azilsartan / chlorthalidone) can cause dizziness, especially when you first start taking it or when your dose goes up. These symptoms should lessen as you continue taking the medication. Stand up slowly from sitting or lying positions to prevent falls. Let your prescriber know if you feel faint, lightheaded, or confused.

            • It's best to avoid or limit how much alcohol you drink while you're taking Edarbyclor (azilsartan / chlorthalidone). Drinking regularly, especially in high amounts, can make your blood pressure get higher. Alcohol might also raise your risk for side effects like feeling dizzy or lightheaded.

              • Tell your care team about the medications you're taking or planning to take. They can check that your medications are safe to take together. This is because Edarbyclor (azilsartan / chlorthalidone) can interact with many medications, including nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen (Advil).

                • Speak with your prescriber right away if you're pregnant or thinking of getting pregnant and you're taking Edarbyclor (azilsartan / chlorthalidone). This medication can harm an unborn baby if it's taken while you're pregnant. Your prescriber will switch you to a different medication that's safe during pregnancy.

                  • It's not recommended to breastfeed while you're taking Edarbyclor (azilsartan / chlorthalidone). It's not known whether this medication is safe for you or your baby while breastfeeding. To be safe, discuss with your prescriber about possibly switching to a different blood pressure medication.

                    faqs

                    Frequently asked questions about Edarbyclor (azilsartan / chlorthalidone)

                    How well does Edarbyclor (azilsartan / chlorthalidone) work?
                    Edarbyclor (azilsartan / chlorthalidone) contains two first-choice medications that work well to lower blood pressure. In clinical studies, the systolic blood pressure (the "top number") dropped by an average of about 40 mmHg for people who took azilsartan and chlorthalidone together for 2 months. Note that everyone can have a different experience taking Edarbyclor (azilsartan / chlorthalidone). Your prescriber will keep track of your progress while you're taking this medication and adjust your treatment plan when needed.
                    How long does it take for Edarbyclor (azilsartan / chlorthalidone) to work?
                    You might have a change in your blood pressure within hours of taking Edarbyclor (azilsartan / chlorthalidone). But it can take about 1 to 2 weeks to see the full blood pressure-lowering effect of this medication. Note that it can take a few weeks before your prescriber finds a stable dose that works best for you since you might need dose adjustments depending on your blood pressure readings. Your prescriber might add another blood pressure medication on top of Edarbyclor (azilsartan / chlorthalidone) if your blood pressure is still too high. Make sure to be patient, continue to take Edarbyclor (azilsartan / chlorthalidone), and follow up with your prescriber regularly.
                    How long does Edarbyclor (azilsartan / chlorthalidone) stay in your system?
                    Since Edarbyclor (azilsartan / chlorthalidone) is made up of two medications, each medication stays in your system for a different amount of time. It takes about 2.5 days for most of azilsartan and about 9 days for most of chlorthalidone to leave your body after a single dose. This time frame is estimated based on the half-life of azilsartan and chlorthalidone. The medication can stay in the system for a longer period of time for people with kidney problems because Edarbyclor (azilsartan / chlorthalidone) is removed from the body by the kidneys. Talk with your healthcare team if you have any specific concerns related to how long this medication stays in your body.
                    Can Edarbyclor (azilsartan / chlorthalidone) be cut in half?
                    Don't cut Edarbyclor (azilsartan / chlorthalidone) tablets in half unless your healthcare team says it's safe to do so. Edarbyclor (azilsartan / chlorthalidone) is a combination medication, and the tablets don't have a score line (an indented line in the middle of the tablet to cut). It's generally not recommended to cut pills that are combination medications because the two resulting halves might not contain the same amount of the active ingredients. Also, it's difficult to cut a non-scored tablet evenly (even if you're using a pill splitter), which can cause you to take the wrong dose. Speak with your prescriber if you're having trouble swallowing Edarbyclor (azilsartan / chlorthalidone) tablets whole.
                    Is Edarbyclor (azilsartan / chlorthalidone) a beta blocker?
                    No, Edarbyclor isn't a beta blocker. Edarbyclor is a combination of two medications: azilsartan, which is an angiotensin II receptor blocker (ARB), and chlorthalidone, which is a thiazide diuretic. Beta blockers, ARBs, and diuretics all work to lower blood pressure, but they do so in different ways. Ask your healthcare team if you have more questions on the different types of blood pressure medications.
                    Does Edarbyclor (azilsartan / chlorthalidone) cause hair loss?
                    People who took Edarbyclor (azilsartan / chlorthalidone) during clinical studies didn't say that they had hair loss as a side effect of the medication. Contact a healthcare professional if you experience hair loss while you're taking Edarbyclor (azilsartan / chlorthalidone). They can help you figure out possible causes for the hair loss.
                    Does Edarbyclor (azilsartan / chlorthalidone) cause weight gain?
                    Weight gain isn't a typical side effect of Edarbyclor (azilsartan / chlorthalidone). Let your primary care provider or cardiologist know if you experience unusual or unexpected weight gain while you're taking this medication.
                    Is there a generic for Edarbyclor (azilsartan / chlorthalidone)?
                    No, Edarbyclor (azilsartan / chlorthalidone) is currently only available as a brand-name medication.
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                    What are the risks and warnings for Edarbyclor (azilsartan / chlorthalidone)?

                    Edarbyclor (azilsartan / chlorthalidone) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                    risk-warning

                    Not safe during pregnancy

                    Edarbyclor (azilsartan / chlorthalidone) can cause severe and sometimes life-threatening harm to an unborn baby if it's taken during pregnancy. For this reason, you shouldn't take Edarbyclor (azilsartan / chlorthalidone) if you're pregnant. Stop taking Edarbyclor (azilsartan / chlorthalidone) and let your prescriber know right away if you become pregnant while you're taking this medication. They'll recommend safer options to treat your blood pressure.

                    risk-warning

                    Low blood pressure

                    • Risk factors: Not enough fluid in your body | Having diarrhea or vomiting for a long time | Low salt levels in your body | Taking higher doses of diuretic medications | Dialysis

                      Sometimes, taking Edarbyclor (azilsartan / chlorthalidone) can cause your blood pressure to drop too much. This can cause you to feel dizzy, tired, or lightheaded. Having very low blood pressure while you're taking this medication is more likely if you're dehydrated or if you're taking a high dose of a diuretic.

                      Make sure to stay well-hydrated. Sit down slowly while holding onto something and let your care team know if your blood pressure drops too much and you feel dizzy. Get medical help right away if you fall and hit your head.

                      risk-warning

                      Changes in electrolyte levels

                      Edarbyclor (azilsartan / chlorthalidone) can affect the level of certain electrolytes in your body like sodium, potassium, and magnesium. Your prescriber might regularly order blood tests to make sure your electrolytes are at a safe level. Let your care team know if you have a fast heartbeat, weakness, low energy, muscle pain or cramps, less urination than usual, nausea, or vomiting. These can be signs of electrolyte changes in your body.

                      risk-warning

                      Kidney damage and waste buildup due to kidney problems

                      • Risk factors: Severe congestive heart failure | Kidney problems | Not enough fluid in your body | Taking other medications that can cause kidney damage

                        Sometimes, Edarbyclor (azilsartan / chlorthalidone) can cause your kidneys to not work as well. The risk is higher for people who have certain types of kidney problems or severe congestive heart failure. Your prescriber might order lab tests every so often to make sure your kidneys are healthy and working properly. Tell your care team if you're having problems urinating, as this could be a sign that your kidneys aren't working as well.

                        Typically, the kidneys are responsible for getting rid of certain waste products from the body. But when the kidneys don't work as well (like in people with kidney problems), taking Edarbyclor (azilsartan / chlorthalidone) can cause these waste products to build up in the body. Contact your prescriber right away if you have symptoms such as trouble making urine, swelling in your legs, weakness, and confusion.

                        risk-warning

                        Higher risk for gout attacks

                        • Risk factors: History of gout

                          Edarbyclor (azilsartan / chlorthalidone) can cause your body to hang onto uric acid, which can raise your risk of gouty attacks. Let your prescriber know if you have a history of gout.

                          dosage

                          Edarbyclor (azilsartan / chlorthalidone) dosage forms

                          The average cost for 30 tablets of 40mg/25mg of Edarbyclor (azilsartan / chlorthalidone) is $244.79 with a free GoodRx coupon. This is 25.26% off the average retail price of $327.51.
                          tablet
                          Tablet
                          DosageQuantityPrice as low asPrice per unit
                          40mg/12.5mg30 tablets$263.69$8.79
                          40mg/25mg30 tablets$244.79$8.16

                          Typical dosing for Edarbyclor (azilsartan / chlorthalidone)

                          The typical starting dose is 40 mg/12.5 mg (azilsartan/chlorthalidone) by mouth once daily. The maximum dose is 40 mg/25 mg (azilsartan/chlorthalidone) per day.

                          Your prescriber will adjust your dose based on how well Edarbyclor (azilsartan / chlorthalidone) is working to control your blood pressure and whether you're having side effects.

                          interactions

                          Interactions between Edarbyclor (azilsartan / chlorthalidone) and other drugs

                          Edarbyclor (azilsartan / chlorthalidone) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Edarbyclor (azilsartan / chlorthalidone). Please note that only the generic name of each medication is listed below.

                          Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

                          Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                          Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

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                          How much does Edarbyclor (azilsartan / chlorthalidone) cost?

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                          contraindications-icon

                          Edarbyclor (azilsartan / chlorthalidone) contraindications

                          Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Edarbyclor (azilsartan / chlorthalidone) will not be safe for you to take.
                          alternatives

                          What are alternatives to Edarbyclor (azilsartan / chlorthalidone)?

                          There are a number of medications that your doctor can prescribe in place of Edarbyclor (azilsartan / chlorthalidone). Compare a few possible alternatives below.
                          Edarbyclor (azilsartan / chlorthalidone)
                          Used for:
                          $244.79 Lowest GoodRx priceView Prices
                          Benicar HCT (olmesartan / hydrochlorothiazide)
                          Used for:

                          • High blood pressure

                          $17.82 Lowest GoodRx priceView Prices
                          Hyzaar (losartan / hydrochlorothiazide)
                          Used for:
                          $11.03 Lowest GoodRx priceView Prices
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                          Edarbyclor (azilsartan / chlorthalidone) images

                          Red Round A / C 40 / 25 - Edarbyclor 40mg-25mg Tablet
                          This medicine is Red, Round Tablet Imprinted With "A/C 40/25".Red Round A / C 40 / 25 - Edarbyclor 40mg-25mg Tablet

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                          References

                          Best studies we found

                          MedlinePlus. (2023). Uric acid - blood.

                          Pharma Packaging Solutions, LLC dba Tjoapack LLC. (2024). Edarbyclor- azilsartan kamedoxomil and chlorthalidone tablet [package insert]. DailyMed.

                          GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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