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Demeclocycline

Demeclocycline Side Effects

Yen Nguyen, PharmDAshley Wong, PharmD
Reviewed by Yen Nguyen, PharmD, Ashley Wong, PharmD
Last reviewed on November 19, 2021

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Diarrhea
  • Stomach pain
  • Nausea
  • Vomiting
  • Teeth discoloration in children
  • Sunburns

Less Common Side Effects

  • Liver problems
  • Ulcers in esophagus (tube connecting your throat and stomach)
  • Skin rash
  • Darkening of the skin
  • Skin lesions on the penis
  • Ringing in your ears
  • Changes in vision
  • Headache
  • Dizziness
  • Loss of appetite
  • Tongue swelling
  • Trouble swallowing

Demeclocycline serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Serious skin reactions: hives, swelling of the skin, joint pain, swelling of the blood vessels, swelling of the heart, lupus-like conditions, difficulty breathing due to lung problems
  • Sudden kidney problems: shortness of breath, tiredness, confusion, nausea, weakness, abnormal heartbeat, swelling in legs, ankles, or feet
  • High pressure in the brain: bulging in the soft spot in your baby's head (fontanel), dizziness, headache, ringing in the ear, blurred vision
  • Severe diarrhea caused by a bacteria called C. difficile: severe diarrhea, fever, stomach pain, loss of appetite, throwing up
  • Serious allergic reactions: trouble breathing, hives, swelling of your face, lips, tongue, or throat

Source: DailyMed

The following Demeclocycline side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

For all tetracyclines

More common

Increased sensitivity of skin to sunlight (rare with minocycline)

Rare

Abdominal pain

bulging fontanel (soft spot on head) of infants

headache

loss of appetite

nausea and vomiting

visual changes

yellowing skin

For demeclocycline only

Less common

Greatly increased frequency of urination or amount of urine

increased thirst

unusual tiredness or weakness

For minocycline only

Less common

Pigmentation (darker color or discoloration) of skin and mucous membranes

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For all tetracyclines

More common

Cramps or burning of the stomach

diarrhea

Less common

Itching of the rectal or genital (sex organ) areas

sore mouth or tongue

For minocycline only

More common

Dizziness, light-headedness, or unsteadiness

In some patients tetracyclines may cause the tongue to become darkened or discolored. This effect is only temporary and will go away when you stop taking this medicine.

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Yen Nguyen, PharmD
Reviewed by:
Yen Nguyen, PharmD
Yen Nguyen, PharmD, is a community pharmacist with a passion for patient education. She earned her doctorate in pharmacy from University of the Pacific.
Ashley Wong, PharmD, is a licensed pharmacist in California. She has over 6 years of experience providing drug information.

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