The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Low appetite (26%)
- Headache (up to 15%)
- Trouble sleeping (up to 13%)
- Nausea (up to 12%)
- Feeling irritable (up to 11%)
- Vomiting (up to 10%)
- Weight loss (up to 9%)
- Stomach pain (up to 7%)
- Dizziness (up to 6%)
Less Common Side Effects
- Blurry vision
- Fatigue
- Nervousness
- Application site reaction (e.g., redness, itchy)
- Rash
Daytrana serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Allergic reactions: rash; hives; swelling or blisters where the patch is applied; difficulty breathing; swelling of face, lips, tongue, or throat
- Heart problems: heart attack, fast heart rate, high blood pressure
- Brain-related problems: seizures, stroke
- Mental health-related problems: manic episodes, changes in thoughts or behavior, hallucinations
- Prolonged and painful erection (lasting several hours)
- Accidentally take too much medication (overdose): restlessness, quick breathing, fast heartbeat, irritability, aggression, fever
Source: DailyMed
More on Daytrana side effects

The following Daytrana side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
More common
Aggressive and violent behavior
arm, back, or jaw pain
black, tarry stools
blistering, peeling, or loosening of the skin
blood in the urine
bloody nose
chest pain or discomfort
chest tightness or heaviness
chills
confusion
cough or hoarseness
cracks in the skin
crying
depersonalization
dizziness
dysphoria
euphoria
fainting
fast, pounding, or irregular heartbeat or pulse
flu-like symptoms
heavier menstrual periods
joint or muscle pain
loss of heat from the body
nervousness
paranoia
pinpoint red spots on the skin
quick to react or overreact emotionally
rapidly changing moods
red, irritated eyes
red, swollen skin
seeing, hearing, or feeling things that are not there
severe or sudden headache
skin rash or itching
sores, ulcers, or white spots in the mouth or on the lips
sudden loss of coordination
sudden slurring of speech
sweating
twitching, twisting, or uncontrolled repetitive movements of the tongue, lips, face, arms, or legs
unusual bleeding or bruising
unusual tiredness or weakness
Rare
Convulsions
difficulty with breathing
high fever
increased sweating
loss of bladder control
severe muscle stiffness
tiredness
uncontrolled vocal outbursts or tics (uncontrolled repeated body movements)
unusually pale skin
Incidence not known
Blistering, burning, crusting, dryness, or flaking of the skin
difficulty with swallowing
hives, itching, scaling, severe redness, soreness, or swelling of the skin
large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
painful or difficult urination
pale skin
paleness or cold feeling in the fingertips and toes
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
swollen glands
tingling or pain in the fingers or toes when exposed to cold
troubled breathing with exertion
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Abdominal or stomach pain
decreased weight
difficulty with moving
drowsiness
headache
loss of appetite
muscle pain or stiffness
redness of the skin
trouble sleeping
vomiting
welts
Incidence not known
Bigger, dilated, or enlarged pupils (black part of the eye)
bleeding, bruising, burning, itching, redness, skin rash, swelling, or soreness at the application site
blurred or loss of vision
disturbed color perception
double vision
halos around lights
increased sensitivity of the eyes to light
night blindness
overbright appearance of lights
thinning of the hair
tunnel vision
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
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