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Low Libido

If Antidepressants Are Ruining Your Sex Drive, Here Are 5 Tips that May Help

Lauren Smith, MABrian Clista, MD
Written by Lauren Smith, MA | Reviewed by Brian Clista, MD
Updated on January 17, 2026
Reviewed by Brian Clista, MD | January 17, 2026

A common side effect from selective serotonin reuptake inhibitors (SSRIs) is sexual dysfunction. Both depression and the medications to treat depression are linked to a low libido, as well as difficulties getting aroused, having adequate lubrication, and reaching orgasm. For some people, that’s reason enough to want to avoid taking antidepressants.

But you can work with your doctor to tweak your treatment plan to maximize effectiveness and minimize side effects. Instead of skipping treatment and possibly allowing your depression to worsen, talk to your doctor about these strategies that may help bring the sex drive back.

References

Centers for Disease Control and Prevention. (2011). Antidepressant use in persons aged 12 and over: United States, 2005-2008.

Diehl, A, et al. (2013). Female sexual dysfunction in patients with substance-related disorders. Clinics (Sao Paolo).

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Lauren Smith, MA
Written by:
Lauren Smith, MA
Lauren Smith, MA, has worked in health journalism since 2017. Before joining GoodRx, she was the senior health editor and writer for HealthiNation.
Brian Clista, MD
Reviewed by:
Brian Clista, MD
Dr. Clista is a board-certified pediatrician who works in private practice in Pittsburgh, Pennsylvania. He previously served as a National Health Service Corporation Scholar in the inner city of Pittsburgh for 11 years.

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