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Epilepsy

Epilepsy vs. Isolated Seizure: What’s the Difference?

Brittany DoohanSanjai Sinha, MD
Written by Brittany Doohan | Reviewed by Sanjai Sinha, MD
Updated on December 8, 2025
Featuring Padmaja Kandula, MD, FAES, FACNSReviewed by Sanjai Sinha, MD | December 8, 2025

If you look inside the brain during the seizure, it resembles a full-on lightning storm. The brain contains billions of neurons (nerve cells) that communicate with each other by creating and receiving electrical impulses.

When someone comes to the emergency room with a seizure, doctors need to determine if the seizure was a one-time, correctable event, if there’s a chance the person may have another seizure, or if they may have a condition called epilepsy.

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Brittany Doohan
Written by:
Brittany Doohan
Brittany Doohan was the Content Director at HealthiNation and is currently the Editorial Director at Medscape. Through her work with Medscape, she won a Silver Telly Award in May 2022 for "Sleepless Nation: A Public Health Epidemic — Episode 2: A Decade Without a Diagnosis." She has worked in health journalism and video production for more than 8 years, and loves the challenge of explaining complex topics in an easy-to-understand and creative way.
Sanjai Sinha, MD
Reviewed by:
Sanjai Sinha, MD
Sanjai Sinha, MD, is a board-certified physician with over 20 years of experience. He specializes in internal medicine.

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