The cholera vaccine, Vaxchora, reduces the risk of getting cholera. It's an oral vaccine you take at your healthcare professional's office at least 10 days before traveling to an area affected by cholera. Vaxchora works by introducing a weakened version of the Vibrio cholerae bacteria to the body, which makes copies of itself in your gut. Your immune system then makes antibodies against the bacteria. These antibodies will help you fight against an actual V. cholerae infection if you encounter it.