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Vagifem vs. Estring

Vagifem (estradiol vaginal insert) is used to treat vaginal dryness, irritation, and burning caused by menopause. It contains estradiol, a type of estrogen that helps to raise your hormone levels to ease these symptoms. You'll usually use one insert with an applicator twice a week (after using it daily for the first 2 weeks). Common side effects include back pain, diarrhea, and vaginal yeast infection.

• Vaginal dryness, burning, and irritation due to menopause

• Vaginal yeast infections (8%)
• Vaginal itching (8%)
• Back pain (7%)
• Diarrhea (5%)

• Risk for blood clots and related complications
• Risk for uterine cancer (also called endometrial cancer)
• Risk for breast cancer
• Risk for ovarian cancer
• Risk for dementia
• Gallbladder or liver problems in certain people
• High triglyceride (fat) levels
• Changes in calcium levels in certain people
• Low thyroid hormone levels
• Buildup of fluids in your body (fluid retention)
• Worsening of certain other health conditions
• Vaginal irritation with applicator use

Estring (estradiol) is an estrogen vaginal ring used as part of hormone replacement therapy (HRT) to treat moderate-to-severe menopause symptoms in and around the vagina, such as vaginal dryness, burning, and irritation. The ring is inserted into the vagina and stays in place for 3 months, releasing a steady dose of estrogen directly where it's needed. Common side effects include headache, vaginal discharge, and vaginal yeast infections.

• Vaginal dryness, burning, and irritation due to menopause

• Headache (13%)
• Vaginal discharge (7%)
• Vaginal yeast infection (6%)
• Back pain (6%)
• Vaginal inflammation (5%)
• Vaginal discomfort or pain (5%)
• Upper respiratory infection (5%)
• Vaginal bleeding (4%)
• Bacterial growth in the vagina (4%)
• Arthritis (4%)
• Trouble sleeping (4%)
• Stomach pain (4%)
• Sinus inflammation (4%)
• Nausea (3%)
• Flu-like symptoms (3%)
• Joint pain (3%)

• Risk for blood clots and related complications
• Risk for uterine cancer (also called endometrial cancer)
• Risk for breast cancer
• Risk for ovarian cancer
• Risk for dementia
• Gallbladder or liver problems in certain people
• High triglyceride (fat) levels
• Changes in calcium levels in certain people
• Low thyroid hormone levels
• Buildup of fluids in your body (fluid retention)
• Worsening of certain other health conditions
• Vaginal irritation and infections