Key takeaways
Tadalafil (Cialis) and sildenafil (Viagra) are both medications used to treat erectile dysfunction (ED), but they have some key differences. Tadalafil can also treat benign prostatic hyperplasia (BPH), while sildenafil is only approved for ED. Tadalafil can be taken either as needed or daily, offering more flexibility, whereas sildenafil is only taken as needed. Tadalafil lasts up to 36 hours, providing a longer window of effectiveness compared to sildenafil, which lasts up to 4 hours. Both medications are available as lower-cost generics. Common side effects for both include headaches, flushining, and indigestion. Neither medication should not be taken with nitrates due to the risk of dangerously low blood pressure.
