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Skytrofa vs. Omnitrope

Skytrofa (lonapegsomatropin or lonapegsomatropin-tcgd) is a prescription growth hormone therapy used to treat children 1 year and older with low growth hormone levels. It's given as a weekly injection under the skin using an autoinjector, which can be done at home. Common side effects include viral infection, fever, cough, nausea, and vomiting.

• Low growth hormone levels in children 1 year and older and who weigh at least 11.5 kg (25 lbs).

• Viral infection (15%)
• Fever (15%)
• Cough (11%)
• Nausea and vomiting (11%)

• Higher risk of death in people with a short-term critical illness
• Severe allergic reactions
• New or worsening cancer
• High blood sugar
• High blood pressure in the brain (intracranial hypertension)
• Swelling in the body
• Low hormone levels
• Bone problems
• Inflammation of the pancreas (pancreatitis)
• Sudden death in children with Prader-Willi syndrome

Omnitrope (somatropin) is a growth hormone therapy used to treat adults and children with low growth hormone. It's also used in children with certain conditions that affect growth, like Prader-Willi syndrome and Turner syndrome. The medication is given as an injection under the skin, usually once a day. Some side effects include headache, swelling, and joint pain.

• Growth problems caused by certain conditions in children (e.g., low growth hormone, Prader-Willi syndrome, small for gestational age, Turner syndrome, idiopathic short stature)
• Low growth hormone in adults

Children

• Bruising (9%)
• Headache (7%)
• Leg pain (5%)

Adults*

• Swelling in the arms and legs (2-18%)
• Joint pain (3-17%)
• Upper respiratory infections (13-16%)
• Pain in the arms and legs (2-15%)

*Adult data comes from a study where a similar growth hormone medication was used.

• Higher risk of death during serious illness
• Higher risk of death in children with Prader-Willi syndrome
• New or returning tumors
• High blood sugar
• High pressure in the brain
• Severe allergic reactions
• Swelling in the body
• Low hormone levels
• Bone and growth changes in children
• Ear infections and heart problems for people with Turner Syndrome
• Fat tissue damage
• Swelling of the pancreas
• Benzyl alcohol warning for infants